PDF(Pubmed)
Abstract：
Melanomas are tumors arising from externally uncontrolled melanocytes that produce varying amounts of melanin. In this study, we report a case of melanoma with neurological impairment without evidence of cutaneous neoplastic lesions in an adult buffalo in the state of Pará, Brazil. Clinically, the buffalo exhibited apathy, decreased mandibular tone, and occasionally an open mouth with motor incoordination, and eventually succumbed to the condition. Necropsy revealed multifocal tumor masses in the brain, pituitary gland, trigeminal ganglion, and spinal cord. The neoplastic cells showed strong positive signals for vimentin, Melan-A, PNL-2, and SOX10. The diagnosis was made via necropsy, histopathology, and positive immunostaining for Melan-A and PNL-2, which are specific markers for melanocyte identification.
摘要：
黑素瘤是由产生不同量的黑色素的外部不受控制的黑色素细胞引起的肿瘤。在这项研究中,我们报告了一例在帕拉州的成年水牛中没有皮肤肿瘤性病变的证据，患有神经系统损害的黑色素瘤，巴西。临床上,水牛表现出冷漠，下颌张力下降，偶尔会张开嘴巴，运动不协调，最终屈服于这种状况。尸检显示大脑中有多灶性肿瘤，脑垂体,三叉神经节,和脊髓。肿瘤细胞显示出强烈的波形蛋白阳性信号，Melan-A,PNL-2和SOX10。诊断是通过尸检,组织病理学,以及Melan-A和PNL-2的阳性免疫染色，它们是黑素细胞鉴定的特异性标记。
