%0 Case Reports
%T Extracutaneous Melanotic Melanoma with Nervous System Involvement in a Buffalo (Bubalus bubalis).
%A Barbosa JD
%A Oliveira MC
%A Oliveira CMC
%A Bomjardim HDA
%A Ferreira TTA
%A Duarte MD
%A da Silveira JAS
%A Silveira NDSES
%A Barbosa CC
%A da Silva AOA
%A Armién A
%A Brito MF
%J Vet Sci
%V 10
%N 12
%D 2023 Nov 21
%M 38133213
%F 2.518
%R 10.3390/vetsci10120662
%X Melanomas are tumors arising from externally uncontrolled melanocytes that produce varying amounts of melanin. In this study, we report a case of melanoma with neurological impairment without evidence of cutaneous neoplastic lesions in an adult buffalo in the state of Pará, Brazil. Clinically, the buffalo exhibited apathy, decreased mandibular tone, and occasionally an open mouth with motor incoordination, and eventually succumbed to the condition. Necropsy revealed multifocal tumor masses in the brain, pituitary gland, trigeminal ganglion, and spinal cord. The neoplastic cells showed strong positive signals for vimentin, Melan-A, PNL-2, and SOX10. The diagnosis was made via necropsy, histopathology, and positive immunostaining for Melan-A and PNL-2, which are specific markers for melanocyte identification.