PDF(Pubmed)
Abstract：
Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, thermosensation is important for survival in all animals. However, mechanisms regulating thermosensation remain unexplored, mostly because of the complexity of mammalian neural circuits. The fruit fly Drosophila melanogaster achieves a desirable body temperature through ambient temperature fluctuations, sunlight exposure, and behavioral strategies. The availability of extensive genetic tools and resources for studying Drosophila have enabled scientists to unravel the mechanisms underlying their temperature preference. Over the past 20 years, Drosophila has become an ideal model for studying temperature-related genes and circuits. This review provides a comprehensive overview of our current understanding of thermosensation and temperature preference in Drosophila. It encompasses various aspects, such as the mechanisms by which flies sense temperature, the effects of internal and external factors on temperature preference, and the adaptive strategies employed by flies in extreme-temperature environments. Understanding the regulating mechanisms of thermosensation and temperature preference in Drosophila can provide fundamental insights into the underlying molecular and neural mechanisms that control body temperature and temperature-related behavioral changes in other animals.
摘要：
温度对动物的所有生理过程都有显着影响。合适的温度可促进反应，运动,新陈代谢，增长,和动物的繁殖，而极端温度会造成伤害甚至死亡.因此，热感觉对所有动物的生存都很重要。然而,调节热感觉的机制仍未被探索，主要是因为哺乳动物神经回路的复杂性。果蝇果蝇通过环境温度波动达到理想的体温，阳光照射,和行为策略。用于研究果蝇的广泛遗传工具和资源的可用性使科学家能够解开其温度偏好的机制。在过去的20年里,果蝇已成为研究温度相关基因和电路的理想模型。这篇综述全面概述了我们目前对果蝇热感觉和温度偏好的理解。它包括各个方面，比如苍蝇感知温度的机制，内部和外部因素对温度偏好的影响，以及苍蝇在极端温度环境中采用的适应性策略。了解果蝇中热感觉和温度偏好的调节机制可以提供对控制其他动物体温和温度相关行为变化的潜在分子和神经机制的基本见解。
