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Abstract：
This work devised a simple glycerol-assisted synthesis of a low-Cu2+-doped CoFe2O4 and the electrochemical detection of acetaminophen (AC). During the synthesis, several polyalcohols were tested, indicating the efficiency of glycerin as a cosolvent, aiding in the creation of electrode-modifier nanomaterials. A duration of standing time (eight hours) before calcination produces a decrease in the secondary phase of hematite. The synthesized material was used as an electrode material in the detection of AC. In acidic conditions (pH 2.5), the limit of detection (LOD) was 99.4 nM, while the limit of quantification (LOQ) was found to be (331 nM). The relative standard deviation (RSD), 3.31%, was computed. The enhanced electrocatalytic activity of a low-Cu2+-doped CoFe2O4-modified electrode Cu0.13Co0.87Fe2O4/GCE corresponds extremely well with its resistance Rct, which was determined using the electrochemical impedance spectroscopy (EIS) technique and defined its electron transfer capacity. The possibility of a low-Cu2+-doped CoFe2O4 for the electrochemical sensing of AC in human urine samples was studied. The recovery rates ranging from 96.5 to 101.0% were obtained. These findings suggested that the Cu0.13Co0.87Fe2O4/GCE sensor has outstanding practicability and could be utilized to detect AC content in real complex biological samples.
摘要：
这项工作设计了一种简单的甘油辅助合成的低Cu2掺杂的CoFe2O4和对乙酰氨基酚（AC）的电化学检测。在合成过程中,测试了几种多元醇，表明甘油作为共溶剂的效率，帮助创建电极改性剂纳米材料。煅烧前的放置时间(8小时)使赤铁矿的第二相减少。将合成的材料用作检测AC的电极材料。在酸性条件下（pH2.5），检测限（LOD）为99.4nM，而定量限(LOQ)为(331nM)。相对标准偏差(RSD)，3.31%,是计算的。低掺杂Cu2的CoFe2O4修饰电极Cu0.13Co0.87Fe2O4/GCE的增强的电催化活性与其电阻Rct非常吻合，这是使用电化学阻抗谱（EIS）技术确定的，并定义了其电子转移容量。研究了低掺杂Cu2的CoFe2O4用于人尿液样品中AC的电化学传感的可能性。得到的回收率为96.5-101.0%。这些发现表明，Cu0.13Co0.87Fe2O4/GCE传感器具有出色的实用性，可用于检测实际复杂生物样品中的AC含量。
