PDF(Pubmed)
Abstract：
BACKGROUND: Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated.
METHODS: A 62-year-old Japanese male showed edema, eruption, and rapid deterioration of the renal function after an acute syphilis infection. A renal biopsy showed crescentic glomerulonephritis with C3 deposition in the glomerular capillary wall, and immunostaining for anti-Treponema pallidum antibody was weakly positive in some interstitium and one glomerulus. Electron microscopy revealed the presence of string-shaped structures in the glomerular capillary walls. After treatment with penicillin followed by prednisolone, the renal function and urinary abnormalities, including Treponema pallidum protein, disappeared.
CONCLUSIONS: Crescentic glomerulonephritis associated with syphilis showed a string-shaped deposition in the glomerular capillary and urinary Treponema pallidum protein excretion, and was effectively treated with penicillin and prednisolone.
METHODS: A 62-year-old Japanese male showed edema, eruption, and rapid deterioration of the renal function after an acute syphilis infection. A renal biopsy showed crescentic glomerulonephritis with C3 deposition in the glomerular capillary wall, and immunostaining for anti-Treponema pallidum antibody was weakly positive in some interstitium and one glomerulus. Electron microscopy revealed the presence of string-shaped structures in the glomerular capillary walls. After treatment with penicillin followed by prednisolone, the renal function and urinary abnormalities, including Treponema pallidum protein, disappeared.
CONCLUSIONS: Crescentic glomerulonephritis associated with syphilis showed a string-shaped deposition in the glomerular capillary and urinary Treponema pallidum protein excretion, and was effectively treated with penicillin and prednisolone.
摘要：
背景：新月体肾小球肾炎伴梅毒感染罕见，肾小球毛细血管壁损伤诱导的新月形成的机制尚未阐明。
方法：一名62岁的日本男性出现水肿，喷发,急性梅毒感染后肾功能迅速恶化。肾活检显示新月体肾小球肾炎，肾小球毛细血管壁有C3沉积，在一些间质和一个肾小球中，抗梅毒螺旋体抗体的免疫染色呈弱阳性。电子显微镜显示肾小球毛细血管壁中存在线状结构。在用青霉素和泼尼松龙治疗后，肾功能和泌尿异常，包括梅毒螺旋体蛋白，消失了。
结论：与梅毒相关的新月体肾小球肾炎表现为肾小球毛细血管和尿梅毒螺旋体蛋白排泄的线状沉积，用青霉素和泼尼松龙有效治疗。
方法：一名62岁的日本男性出现水肿，喷发,急性梅毒感染后肾功能迅速恶化。肾活检显示新月体肾小球肾炎，肾小球毛细血管壁有C3沉积，在一些间质和一个肾小球中，抗梅毒螺旋体抗体的免疫染色呈弱阳性。电子显微镜显示肾小球毛细血管壁中存在线状结构。在用青霉素和泼尼松龙治疗后，肾功能和泌尿异常，包括梅毒螺旋体蛋白，消失了。
结论：与梅毒相关的新月体肾小球肾炎表现为肾小球毛细血管和尿梅毒螺旋体蛋白排泄的线状沉积，用青霉素和泼尼松龙有效治疗。
