%0 Review
%T Crescentic glomerulonephritis associated with syphilis: a case report and review of the literature.
%A Kaiga A
%A Sato Y
%A Arakawa H
%A Rai T
%A Tojo A
%J J Med Case Rep
%V 17
%N 1
%D 2023 Dec 22
%M 38129918
暂无%R 10.1186/s13256-023-04293-2
%X <B>BACKGROUND: </B>Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated.<BR><B>METHODS: </B>A 62-year-old Japanese male showed edema, eruption, and rapid deterioration of the renal function after an acute syphilis infection. A renal biopsy showed crescentic glomerulonephritis with C3 deposition in the glomerular capillary wall, and immunostaining for anti-Treponema pallidum antibody was weakly positive in some interstitium and one glomerulus. Electron microscopy revealed the presence of string-shaped structures in the glomerular capillary walls. After treatment with penicillin followed by prednisolone, the renal function and urinary abnormalities, including Treponema pallidum protein, disappeared.<BR><B>CONCLUSIONS: </B>Crescentic glomerulonephritis associated with syphilis showed a string-shaped deposition in the glomerular capillary and urinary Treponema pallidum protein excretion, and was effectively treated with penicillin and prednisolone.