METHODS: PubMed databases were searched for literature on sphingolipids and alcohol use disorder (alcohol abuse, alcohol addiction, alcohol dependence, and alcohol misuse) including evidence of the relationship between sphingolipids-mediated neuroinflammation and alcohol use disorder (formation, withdrawal, treatment).
RESULTS: Disorders of sphingolipid metabolism, including the different types of sphingolipids and regulatory enzyme activity, have been found in patients with alcohol use disorder as well as animal models, which in turn cause neuro-inflammation in the central nervous system. Thus, these disorders may also be an important mechanism in the development of alcohol use disorder in patients. In addition, different sphingolipids may have different or even reverse effects on alcohol use disorder.
CONCLUSIONS: The sphingolipids-mediated neuroinflammation plays an important role in the development of alcohol use disorder. This review proposes a potential approach to prevent and treat alcohol use disorders by manipulating sphingolipid metabolism.
方法:在PubMed数据库中搜索有关鞘脂和酒精使用障碍(酒精滥用,酒精成瘾,酒精依赖,和酒精滥用),包括鞘脂介导的神经炎症和酒精使用障碍(形成,撤回,治疗)。
结果:鞘脂代谢紊乱,包括不同类型的鞘脂和调节酶活性,已经在酒精使用障碍患者以及动物模型中发现,进而引起中枢神经系统的神经炎症。因此,这些疾病也可能是患者酒精使用障碍发展的重要机制。此外,不同的鞘脂对酒精使用障碍可能有不同甚至相反的影响。
结论:鞘脂介导的神经炎症在酒精使用障碍的发展中起重要作用。这篇综述提出了一种通过控制鞘脂代谢来预防和治疗酒精使用障碍的潜在方法。