UNASSIGNED: Included were children aged 0 to 18 years undergoing routine check without history of any renal disease. Cystatin C was measured by the immunoturbidimetric method, and creatinine by the enzymatic method on a Cobas c501 analyzer (Roche Diagnostics, Manheim, Germany). Reference intervals were determined according to the CLSI C28-A3 guidelines using a robust method and a nonparametric percentile method, depending on the sample size. The Schwartz\'s formula was applied to estimate glomerular filtration (eGFR) from cystatin C.
UNASSIGNED: The cystatin C reference interval for children aged 1-18 years (N = 204, median 8 years) was from 0.61 mg/L (90% CI: 0.53 to 0.64) to 1.08 mg/L (90% CI: 1.07 to 1.14). Differences according to sex were not found. For children aged 0-1 years (N = 29, median 5 months), the reference interval was from 0.60 mg/L (90% CI: 0.48 to 0.72) to 1.49 mg/L (90% CI: 1.36 to 1.61). The sample size was too small to test the difference according to sex. The eGFR was 76 (70-88) mL/min/1.73m2 for males and 83 (74-92) mL/min/1.73m2 for females.
UNASSIGNED: The cystatin C reference intervals for Croatian pediatric population according to age were determined. The cystatin C concentrations in children reach adulthood values after the first year. The cystatin C Schwartz\'s formula is applicable for eGFR calculation in children.
■包括0至18岁接受常规检查但无任何肾脏疾病史的儿童。通过免疫比浊法测量胱抑素C,和肌酐通过CobasC501分析仪上的酶法(RocheDiagnostics,曼海姆,德国)。参考间隔是根据CLSIC28-A3指南使用稳健方法和非参数百分位法确定的,取决于样本量。Schwartz公式用于估算胱抑素C的肾小球滤过率(eGFR)。
■1-18岁(N=204,中位数8岁)儿童的胱抑素C参考区间为0.61mg/L(90%CI:0.53至0.64)至1.08mg/L(90%CI:1.07至1.14)。没有发现性别差异。对于0-1岁的儿童(N=29,中位数为5个月),参考区间为0.60mg/L(90%CI:0.48~0.72)~1.49mg/L(90%CI:1.36~1.61).样本量太小,无法根据性别测试差异。eGFR男性为76(70-88)mL/min/1.73m2,女性为83(74-92)mL/min/1.73m2。
■根据年龄确定克罗地亚儿科人群的胱抑素C参考间隔。儿童的胱抑素C浓度在第一年后达到成年期值。胱抑素CSchwartz公式适用于儿童的eGFR计算。