{Reference Type}: Journal Article
{Title}: Determination of cystatin C reference interval for children in Croatia.
{Author}: Cigula Kurajica V;Vogrinc Ž;Turčić A;Galić S;
{Journal}: Biochem Med (Zagreb)
{Volume}: 34
{Issue}: 1
{Year}: 2024 Feb 15
{Factor}: 2.515
{DOI}: 10.11613/BM.2024.010702
{Abstract}: <B>UNASSIGNED: </B>Cystatin C is considered an early marker of kidney damage. The aim was to determine the reference interval in children since this information was not available from the test manufacturer.<BR><B>UNASSIGNED: </B>Included were children aged 0 to 18 years undergoing routine check without history of any renal disease. Cystatin C was measured by the immunoturbidimetric method, and creatinine by the enzymatic method on a Cobas c501 analyzer (Roche Diagnostics, Manheim, Germany). Reference intervals were determined according to the CLSI C28-A3 guidelines using a robust method and a nonparametric percentile method, depending on the sample size. The Schwartz's formula was applied to estimate glomerular filtration (eGFR) from cystatin C.<BR><B>UNASSIGNED: </B>The cystatin C reference interval for children aged 1-18 years (N = 204, median 8 years) was from 0.61 mg/L (90% CI: 0.53 to 0.64) to 1.08 mg/L (90% CI: 1.07 to 1.14). Differences according to sex were not found. For children aged 0-1 years (N = 29, median 5 months), the reference interval was from 0.60 mg/L (90% CI: 0.48 to 0.72) to 1.49 mg/L (90% CI: 1.36 to 1.61). The sample size was too small to test the difference according to sex. The eGFR was 76 (70-88) mL/min/1.73m2 for males and 83 (74-92) mL/min/1.73m2 for females.<BR><B>UNASSIGNED: </B>The cystatin C reference intervals for Croatian pediatric population according to age were determined. The cystatin C concentrations in children reach adulthood values after the first year. The cystatin C Schwartz's formula is applicable for eGFR calculation in children.