IL - 1 阻断治疗可逆转 KRAS 突变 CMML 患者的 NLRP3 炎性体激活和症状负担.
关键词: CMML IL-1 blockers KRAS NLRP3 blockers NLRP3 inflammasome RAS mutations anakinra inflammation myelodysplastic syndromes myeloproliferative neoplasms
Mesh : Humans Inflammasomes / genetics metabolism NLR Family, Pyrin Domain-Containing 3 Protein / genetics metabolism Proto-Oncogene Proteins p21(ras) / genetics metabolism Leukemia, Myelomonocytic, Chronic / drug therapy genetics Symptom Burden Interleukin-1 / metabolism
来 源:
DOI:10.1016/j.xcrm.2023.101329
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