Gsdma1 / 2 / 3 的耗尽通过抑制 EGFR - Stat3 / Akt 途径减轻 PMA 诱导的表皮增生。
关键词: Akt EGFR GSDMA Hb-egf PMA Stat3 epidermal hyperplasia
Mesh : Animals STAT3 Transcription Factor / metabolism ErbB Receptors / metabolism genetics Hyperplasia Proto-Oncogene Proteins c-akt / metabolism Tetradecanoylphorbol Acetate / pharmacology Signal Transduction / drug effects Mice, Knockout Epidermis / pathology metabolism drug effects Keratinocytes / metabolism pathology Mice Mice, Inbred C57BL Gasdermins
来 源:
DOI:10.1093/jmcb/mjad080
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