PDF(Pubmed)
Abstract：
Adipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin has been reported to promote vascular derangements, systemic inflammation, and endothelial dysfunction. Prospective and case-control studies showed that this adipokine is directly associated with all-cause death and rehospitalization in patients with coronary artery disease. Adipsin has also been implicated in pulmonary arterial hypertension, abdominal aortic aneurysm, pre-eclampsia, and type-2 diabetes which is a major risk factor for CVD. Importantly, serum adipsin has been recognized as a unique prognostic marker for assessing cardiovascular diseases. At present, there is paucity of experimental evidence about the precise role of adipsin in the etiology of CVD. However, this mini review provides some insight on the contribution of adipsin in the pathogenesis of CVD and highlights its role on endothelial, smooth muscle and immune cells that mediate cardiovascular functions.
摘要：
Adipsin是主要在脂肪组织中合成并释放到循环中的脂肪因子。它也被称为补体因子-D（CFD），作为补体替代途径的限速因子，对补体系统的激活发挥重要作用。在人类中缺乏CFD是非常罕见的病症。然而,补体过度激活与许多疾病的病因有关，包括心血管疾病（CVD）。据报道，增加循环水平的脂肪素促进血管紊乱，全身性炎症,和内皮功能障碍。前瞻性和病例对照研究表明，这种脂肪因子与冠心病患者的全因死亡和再住院直接相关。Adipsin也与肺动脉高压有关，腹主动脉瘤,先兆子痫,2型糖尿病是CVD的主要危险因素。重要的是,血清脂肪素已被认为是评估心血管疾病的独特预后指标。目前,关于脂肪素在CVD病因学中的确切作用的实验证据很少。然而,这篇小型综述提供了一些关于脂肪素在心血管疾病发病机制中的作用的见解，并强调了其在内皮，调节心血管功能的平滑肌和免疫细胞。
