PDF(Pubmed)
Abstract：
UNASSIGNED: Aspartate aminotransferase (AST), an indicator of liver cell damage, was related to the prognosis of certain malignant tumors.
UNASSIGNED: This study examined the predictive value of AST in patients with extranodal natural killer/T cell lymphoma (ENKTL).
UNASSIGNED: We reviewed 183 cases diagnosed with ENKTL and selected 26 U/L as the optimum cut-off value of AST. We used the univariate and multivariate Cox regression to compare the different AST groups\' overall survival (OS) and progression-free survival (PFS).
UNASSIGNED: Prior to propensity score matching (PSM), Kaplan-Meier analysis showed that patients in the low AST subgroup had better OS and PFS than the high AST subgroup. Multivariate analysis revealed that AST was an independent indicator for prognosis. After PSM, the low AST subgroup maintained a significantly better OS and PFS than the high AST subgroup.
UNASSIGNED: AST might represent a significant prognostic marker for ENKTL patients.
UNASSIGNED: This study examined the predictive value of AST in patients with extranodal natural killer/T cell lymphoma (ENKTL).
UNASSIGNED: We reviewed 183 cases diagnosed with ENKTL and selected 26 U/L as the optimum cut-off value of AST. We used the univariate and multivariate Cox regression to compare the different AST groups\' overall survival (OS) and progression-free survival (PFS).
UNASSIGNED: Prior to propensity score matching (PSM), Kaplan-Meier analysis showed that patients in the low AST subgroup had better OS and PFS than the high AST subgroup. Multivariate analysis revealed that AST was an independent indicator for prognosis. After PSM, the low AST subgroup maintained a significantly better OS and PFS than the high AST subgroup.
UNASSIGNED: AST might represent a significant prognostic marker for ENKTL patients.
摘要：
背景：天冬氨酸氨基转移酶（AST），肝细胞损伤的指标,与某些恶性肿瘤的预后有关。
目的：本研究检查了AST在结外自然杀伤/T细胞淋巴瘤（ENKTL）患者中的预测价值。
方法：我们回顾了183例诊断为ENKTL的病例，并选择26U/L作为AST的最佳临界值。我们使用单变量和多变量Cox回归比较不同AST组的总生存期(OS)和无进展生存期(PFS)。
结果：倾向得分匹配(PSM)之前，Kaplan-Meier分析显示，低AST亚组患者的OS和PFS优于高AST亚组。多因素分析显示AST是预后的独立指标。PSM之后,低AST亚组的OS和PFS明显优于高AST亚组。
结论：AST可能代表ENKTL患者的重要预后指标。
目的：本研究检查了AST在结外自然杀伤/T细胞淋巴瘤（ENKTL）患者中的预测价值。
方法：我们回顾了183例诊断为ENKTL的病例，并选择26U/L作为AST的最佳临界值。我们使用单变量和多变量Cox回归比较不同AST组的总生存期(OS)和无进展生存期(PFS)。
结果：倾向得分匹配(PSM)之前，Kaplan-Meier分析显示，低AST亚组患者的OS和PFS优于高AST亚组。多因素分析显示AST是预后的独立指标。PSM之后,低AST亚组的OS和PFS明显优于高AST亚组。
结论：AST可能代表ENKTL患者的重要预后指标。
