PDF(Pubmed)
Abstract：
Epigenetic modifications of RNA significantly contribute to the regulatory processes in tumors and have, thus, received considerable attention. The m6A modification, known as N6-methyladenosine, is the predominant epigenetic alteration found in both eukaryotic mRNAs and ncRNAs.
m6A methylation modifications are dynamically reversible and are catalyzed, removed, and recognized by the complex of m6A methyltransferase (MTases), m6A demethylase, and m6A methyl recognition proteins (MRPs). Published evidence suggests that dysregulated m6A modification results in abnormal biological behavior of mature mRNA, leading to a variety of abnormal physiological processes, with profound implications for tumor development in particular.
Abnormal RNA processing due to dysregulation of m6A modification plays an important role in tumor pathogenesis and potential mechanisms of action. In this review, we comprehensively explored the mechanisms by which m6A modification regulates mRNA and ncRNA processing, focusing on their roles in tumors, and aiming to understand the important regulatory function of m6A modification, a key RNA epigenetic modification, in tumor cells, with a view to providing theoretical support for tumor diagnosis and treatment. Video Abstract.
m6A methylation modifications are dynamically reversible and are catalyzed, removed, and recognized by the complex of m6A methyltransferase (MTases), m6A demethylase, and m6A methyl recognition proteins (MRPs). Published evidence suggests that dysregulated m6A modification results in abnormal biological behavior of mature mRNA, leading to a variety of abnormal physiological processes, with profound implications for tumor development in particular.
Abnormal RNA processing due to dysregulation of m6A modification plays an important role in tumor pathogenesis and potential mechanisms of action. In this review, we comprehensively explored the mechanisms by which m6A modification regulates mRNA and ncRNA processing, focusing on their roles in tumors, and aiming to understand the important regulatory function of m6A modification, a key RNA epigenetic modification, in tumor cells, with a view to providing theoretical support for tumor diagnosis and treatment. Video Abstract.
摘要：
背景：RNA的表观遗传修饰显着促进肿瘤的调节过程，因此，得到了相当多的关注。M6A修改，被称为N6-甲基腺苷，是在真核mRNAs和ncRNAs中发现的主要表观遗传改变。
方法：m6A甲基化修饰是动态可逆的，并且被催化，已移除,并由m6A甲基转移酶（MTases）的复合物识别，m6A去甲基酶，和m6A甲基识别蛋白(MRP)。已发表的证据表明，m6A修饰失调导致成熟mRNA的异常生物学行为，导致各种异常的生理过程，特别是对肿瘤的发展有着深远的影响。
结论：由于m6A修饰失调导致的RNA加工异常在肿瘤的发病机制和潜在的作用机制中起着重要作用。在这次审查中,我们全面探索了m6A修饰调节mRNA和ncRNA加工的机制，专注于它们在肿瘤中的作用，旨在了解M6A修饰的重要调节功能，一个关键的RNA表观遗传修饰，在肿瘤细胞中，以期为肿瘤的诊断和治疗提供理论支持。视频摘要。
方法：m6A甲基化修饰是动态可逆的，并且被催化，已移除,并由m6A甲基转移酶（MTases）的复合物识别，m6A去甲基酶，和m6A甲基识别蛋白(MRP)。已发表的证据表明，m6A修饰失调导致成熟mRNA的异常生物学行为，导致各种异常的生理过程，特别是对肿瘤的发展有着深远的影响。
结论：由于m6A修饰失调导致的RNA加工异常在肿瘤的发病机制和潜在的作用机制中起着重要作用。在这次审查中,我们全面探索了m6A修饰调节mRNA和ncRNA加工的机制，专注于它们在肿瘤中的作用，旨在了解M6A修饰的重要调节功能，一个关键的RNA表观遗传修饰，在肿瘤细胞中，以期为肿瘤的诊断和治疗提供理论支持。视频摘要。
