Abstract：
The use of reactive gaseous reagents for the production of active pharmaceutical ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The implementation of continuous-flow reactors has resulted in rapid development of gas-handling technology because of several advantages such as increased interfacial area, improved mass- and heat transfer, and seamless scale-up. This technology enables shorter and more atom-economic synthesis routes for the production of pharmaceutical compounds. Herein, we provide an overview of literature from 2016 onwards in the development of gas-handling continuous-flow technology as well as the use of gases in functionalization of APIs.
摘要：
由于安全性和效率限制,用于生产活性药物成分(API)的反应性气态试剂的使用仍然是科学挑战。连续流动反应器的实施导致快速发展的气体处理技术，因为几个优点，如增加界面面积，改善质量和传热，无缝扩展。该技术能够实现用于生产药物化合物的更短和更原子经济的合成路线。在这里，我们提供了从2016年起在气体处理连续流技术的发展以及在原料药功能化中使用气体方面的文献综述。
