PDF(Pubmed)
Abstract：
OBJECTIVE: Syphilis is an ancient disease of humans and lagomorphs caused by two distinct but genetically closely related bacteria (>98% sequence identity based on the whole genome) of the genus Treponema. While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative studies are needed to understand mechanisms in host-pathogen coevolution in treponematoses. Importantly, Treponema paraluisleporidarum-infected hare populations provide ample opportunity to study the syphilis-causing pathogen in a naturally infected model population without antibiotic treatment, data that cannot be obtained from syphilis infection in humans. We provide data on genetic diversity and are able to highlight various types of repetitions in one of the two hypervariable regions at the tp0548 locus that have not been described in the human syphilis-causing sister bacterium Treponema pallidum subsp. pallidum.
摘要：
目的：梅毒是由螺旋体属的两种不同但遗传上密切相关的细菌（基于整个基因组的序列同一性>98％）引起的人类和lagomorphs的古老疾病。虽然人类梅毒研究得很好，人们对这种病在lagomorph宿主中知之甚少。然而，需要进行比较研究以了解螺旋体病中宿主-病原体共同进化的机制。重要的是,副猪螺旋体感染的野兔群体提供了充分的机会，可以在没有抗生素治疗的自然感染模型人群中研究引起梅毒的病原体。无法从人类梅毒感染中获得的数据。我们提供了有关遗传多样性的数据，并能够突出显示tp0548基因座的两个高变区之一中的各种类型的重复，这些重复在引起人类梅毒的姐妹细菌梅毒螺旋体亚种中尚未描述。苍白球.
