PDF(Pubmed)
Abstract：
BACKGROUND: Interferon-gamma release assay (IGRA) is the main tool for the diagnosis of latent tuberculosis (TB) infection (LTBI). However, the indeterminate results were more frequent in children, and the underlying reasons were largely speculative. We aimed to compare QuantiFERON-TB Gold In-Tube (QFT-GIT) with X.DOT-TB (XDOT) for diagnosing LTBI, and to identify the risk factors associated with indeterminate results in children.
METHODS: A retrospective study for children<18 years old, at risk for LTBI or progression to TB disease, received either QFT-GIT or X.DOT-TB tests was performed at Beijing Children\'s Hospital from August 2019 to August 2022.
RESULTS: A total of 33,662 children were recruited, including 15,129 (44.9%) tested with X.DOT-TB and 18,533 (55.1%) with QFT-GIT. Proportion of positive and indeterminate results in children with respiratory disease was significantly higher than did that with other diseases, respectively (P < 0.001). The indeterminate rate of X.DOT-TB and QFT-GIT results decreased with increasing age (P < 0.001). Proportion of QFT-GIT indeterminate results was higher than that of X.DOT-TB across age groups. Male, age and disease classification all presented a statistically significant association with indeterminate IGRA results.
CONCLUSIONS: The positive rates of X.DOT-TB and QFT-GIT in children were 3.1% and 1.8%, respectively. The X.DOT-TB assay performed better than QFT-GIT in children, and male, age and underlying diseases were associated with an increased risk of indeterminate IGRA results.
METHODS: A retrospective study for children<18 years old, at risk for LTBI or progression to TB disease, received either QFT-GIT or X.DOT-TB tests was performed at Beijing Children\'s Hospital from August 2019 to August 2022.
RESULTS: A total of 33,662 children were recruited, including 15,129 (44.9%) tested with X.DOT-TB and 18,533 (55.1%) with QFT-GIT. Proportion of positive and indeterminate results in children with respiratory disease was significantly higher than did that with other diseases, respectively (P < 0.001). The indeterminate rate of X.DOT-TB and QFT-GIT results decreased with increasing age (P < 0.001). Proportion of QFT-GIT indeterminate results was higher than that of X.DOT-TB across age groups. Male, age and disease classification all presented a statistically significant association with indeterminate IGRA results.
CONCLUSIONS: The positive rates of X.DOT-TB and QFT-GIT in children were 3.1% and 1.8%, respectively. The X.DOT-TB assay performed better than QFT-GIT in children, and male, age and underlying diseases were associated with an increased risk of indeterminate IGRA results.
摘要：
背景：干扰素-γ释放测定（IGRA）是诊断潜伏性结核病（TB）感染（LTBI）的主要工具。然而,不确定的结果在儿童中更常见，根本原因主要是投机性的。我们旨在比较QuantiFERON-TB金管（QFT-GIT）和X.DOT-TB（XDOT）用于诊断LTBI，并确定与儿童不确定结果相关的危险因素。
方法：一项针对18岁以下儿童的回顾性研究，有LTBI或进展为结核病的风险，2019年8月至2022年8月在北京儿童医院接受了QFT-GIT或X.DOT-TB检测.
结果：总共招募了33,662名儿童，包括使用X.DOT-TB测试的15,129（44.9%）和使用QFT-GIT测试的18,533（55.1%）。呼吸道疾病患儿的阳性和不确定结果的比例明显高于其他疾病患儿，分别(P<0.001)。X.DOT-TB和QFT-GIT结果的不确定率随年龄增加而降低(P<0.001)。各年龄组QFT-GIT不确定结果的比例高于X.DOT-TB。男性,年龄和疾病分类均与不确定的IGRA结果存在统计学显著关联.
结论：儿童X.DOT-TB和QFT-GIT的阳性率分别为3.1％和1.8％，分别。X.DOT-TB检测在儿童中的表现优于QFT-GIT，男性，年龄和基础疾病与IGRA结果不确定的风险增加相关.
方法：一项针对18岁以下儿童的回顾性研究，有LTBI或进展为结核病的风险，2019年8月至2022年8月在北京儿童医院接受了QFT-GIT或X.DOT-TB检测.
结果：总共招募了33,662名儿童，包括使用X.DOT-TB测试的15,129（44.9%）和使用QFT-GIT测试的18,533（55.1%）。呼吸道疾病患儿的阳性和不确定结果的比例明显高于其他疾病患儿，分别(P<0.001)。X.DOT-TB和QFT-GIT结果的不确定率随年龄增加而降低(P<0.001)。各年龄组QFT-GIT不确定结果的比例高于X.DOT-TB。男性,年龄和疾病分类均与不确定的IGRA结果存在统计学显著关联.
结论：儿童X.DOT-TB和QFT-GIT的阳性率分别为3.1％和1.8％，分别。X.DOT-TB检测在儿童中的表现优于QFT-GIT，男性，年龄和基础疾病与IGRA结果不确定的风险增加相关.
