METHODS: A retrospective study for children<18 years old, at risk for LTBI or progression to TB disease, received either QFT-GIT or X.DOT-TB tests was performed at Beijing Children\'s Hospital from August 2019 to August 2022.
RESULTS: A total of 33,662 children were recruited, including 15,129 (44.9%) tested with X.DOT-TB and 18,533 (55.1%) with QFT-GIT. Proportion of positive and indeterminate results in children with respiratory disease was significantly higher than did that with other diseases, respectively (P < 0.001). The indeterminate rate of X.DOT-TB and QFT-GIT results decreased with increasing age (P < 0.001). Proportion of QFT-GIT indeterminate results was higher than that of X.DOT-TB across age groups. Male, age and disease classification all presented a statistically significant association with indeterminate IGRA results.
CONCLUSIONS: The positive rates of X.DOT-TB and QFT-GIT in children were 3.1% and 1.8%, respectively. The X.DOT-TB assay performed better than QFT-GIT in children, and male, age and underlying diseases were associated with an increased risk of indeterminate IGRA results.
方法:一项针对18岁以下儿童的回顾性研究,有LTBI或进展为结核病的风险,2019年8月至2022年8月在北京儿童医院接受了QFT-GIT或X.DOT-TB检测.
结果:总共招募了33,662名儿童,包括使用X.DOT-TB测试的15,129(44.9%)和使用QFT-GIT测试的18,533(55.1%)。呼吸道疾病患儿的阳性和不确定结果的比例明显高于其他疾病患儿,分别(P<0.001)。X.DOT-TB和QFT-GIT结果的不确定率随年龄增加而降低(P<0.001)。各年龄组QFT-GIT不确定结果的比例高于X.DOT-TB。男性,年龄和疾病分类均与不确定的IGRA结果存在统计学显著关联.
结论:儿童X.DOT-TB和QFT-GIT的阳性率分别为3.1%和1.8%,分别。X.DOT-TB检测在儿童中的表现优于QFT-GIT,男性,年龄和基础疾病与IGRA结果不确定的风险增加相关.