Abstract：
UNASSIGNED: The aim of this review is to evaluate the relationship between the use of non-steroidal anti-inflammatory drugs (NSAIDs) during last trimesters of the pregnancy and the reduction of amniotic fluid.
UNASSIGNED: Electronic databases were searched (PubMed, Medline, and Scopus). Selection criteria included studies reporting the relationship between oligohydramnios and use of NSAID during pregnancy. We analyzed the median age of women, weeks of pregnancy at the beginning of the drug administration, kind of medication, period of exposure and dosage, deepest vertical pocket (DVP), and amniotic fluid index (AFI).
UNASSIGNED: Of the 68 records identified, we analyzed 29 studies investigating the administration of NSAIDs, including 11 studies examined the administration of the Indomethacin, four articles have focused on the use of Nimesulide, and only two manuscripts considered the use of Diclofenac. We found a strict correlation between the development of oligohydramnios and the use of NSAIDs. The oligohydramnios is reversible, and the normal amount of amniotic fluid is restored after the interruption of the treatment.
UNASSIGNED: The use of NSAIDs should be considered when maternal benefits outweigh the potential fetal risk, at the lowest effective dose for shortest duration. Beyond 48 h of NSAIDs treatment, we consider ultrasound monitoring of amniotic fluid, and we suggest stopping therapy if a decline AFI is present.
UNASSIGNED: Electronic databases were searched (PubMed, Medline, and Scopus). Selection criteria included studies reporting the relationship between oligohydramnios and use of NSAID during pregnancy. We analyzed the median age of women, weeks of pregnancy at the beginning of the drug administration, kind of medication, period of exposure and dosage, deepest vertical pocket (DVP), and amniotic fluid index (AFI).
UNASSIGNED: Of the 68 records identified, we analyzed 29 studies investigating the administration of NSAIDs, including 11 studies examined the administration of the Indomethacin, four articles have focused on the use of Nimesulide, and only two manuscripts considered the use of Diclofenac. We found a strict correlation between the development of oligohydramnios and the use of NSAIDs. The oligohydramnios is reversible, and the normal amount of amniotic fluid is restored after the interruption of the treatment.
UNASSIGNED: The use of NSAIDs should be considered when maternal benefits outweigh the potential fetal risk, at the lowest effective dose for shortest duration. Beyond 48 h of NSAIDs treatment, we consider ultrasound monitoring of amniotic fluid, and we suggest stopping therapy if a decline AFI is present.
摘要：
■这篇综述的目的是评估妊娠最后三个月使用非甾体抗炎药（NSAIDs）与羊水减少之间的关系。
■搜索了电子数据库(PubMed，Medline,和Scopus）。选择标准包括报告羊水过少与怀孕期间使用NSAID之间关系的研究。我们分析了女性的平均年龄，在药物施用开始时怀孕几周，一种药物，暴露时间和剂量，最深的垂直口袋（DVP），羊水指数（AFI）。
■在确定的68条记录中，我们分析了29项研究NSAIDs的使用情况，包括11项研究检查了吲哚美辛的给药，四篇文章集中讨论了尼美舒利的使用，只有两份手稿考虑使用双氯芬酸。我们发现羊水过少的发展与NSAIDs的使用之间存在严格的相关性。羊水过少是可逆的,治疗中断后羊水恢复正常。
■当产妇的益处大于潜在的胎儿风险时，应考虑使用非甾体抗炎药，在最短的持续时间的最低有效剂量。超过48小时的NSAIDs治疗，我们考虑超声监测羊水，如果AFI下降，我们建议停止治疗。
■搜索了电子数据库(PubMed，Medline,和Scopus）。选择标准包括报告羊水过少与怀孕期间使用NSAID之间关系的研究。我们分析了女性的平均年龄，在药物施用开始时怀孕几周，一种药物，暴露时间和剂量，最深的垂直口袋（DVP），羊水指数（AFI）。
■在确定的68条记录中，我们分析了29项研究NSAIDs的使用情况，包括11项研究检查了吲哚美辛的给药，四篇文章集中讨论了尼美舒利的使用，只有两份手稿考虑使用双氯芬酸。我们发现羊水过少的发展与NSAIDs的使用之间存在严格的相关性。羊水过少是可逆的,治疗中断后羊水恢复正常。
■当产妇的益处大于潜在的胎儿风险时，应考虑使用非甾体抗炎药，在最短的持续时间的最低有效剂量。超过48小时的NSAIDs治疗，我们考虑超声监测羊水，如果AFI下降，我们建议停止治疗。
