关键词: Biological activity Extracellular polysaccharide structure Food industry Lactic acid bacteria Structure-activity relationship

Mesh : Humans Lactobacillales / metabolism Polysaccharides, Bacterial / chemistry Structure-Activity Relationship Food Industry Probiotics

来  源:   DOI:10.1016/j.ijbiomac.2023.128733

Abstract:
Over the past few decades, researchers have discovered that probiotics play an important role in our daily lives. With the further deepening of research, more and more evidence show that bacterial metabolites have an important role in food and human health, which opens up a new direction for the research of lactic acid bacteria (LAB) in the food and pharmaceutical industry. Many LAB have been widely studied because of the ability of exopolysaccharides (EPS). Lactic acid bacteria exopolysaccharides (LAB EPS) not only have great potential in the treatment of human diseases but also can become natural ingredients in the food industry to provide special qualitative structure and flavor. This paper has organized and summarized the biosynthesis, strain selection, production process parameters, structure, and biological activity of LAB EPS, filling in the monotony and incompleteness of previous articles\' descriptions of LAB EPS. Therefore, this paper focuses on the general biosynthetic pathway, structural characterization, structure-activity relationship, biological activity of LAB EPS, and their application in the food industry, which will help to deepen people\'s understanding of LAB EPS and develop new active drugs from LAB EPS. Although the research results are relatively affluent, the low yield, complex structure, and few clinical trials of EPS are still the reasons that hinder its development. Therefore, future knowledge expansion should focus on the regulation of structure, physicochemical properties, function, higher production of EPS, and clinical trial applications, which can further increase the commercial significance and value of EPS. Furthermore, better understanding the structure-function relationship of EPS in food remains a challenge to date.
摘要:
在过去的几十年里,研究人员发现,益生菌在我们的日常生活中起着重要的作用。随着研究的进一步深入,越来越多的证据表明,细菌代谢产物在食品和人类健康中具有重要作用,为乳酸菌(LAB)在食品和医药行业的研究开辟了新的方向。由于胞外多糖(EPS)的能力,许多LAB已被广泛研究。乳酸菌胞外多糖(LABEPS)不仅在治疗人类疾病方面具有巨大潜力,而且可以成为食品工业中提供特殊定性结构和风味的天然成分。本文对生物合成、应变选择,生产工艺参数,结构,和LABEPS的生物活性,填补了以前文章对LABEPS的描述的单调和不完整。因此,本文重点介绍了一般的生物合成途径,结构表征,构效关系,LABEPS的生物活性,以及它们在食品工业中的应用,这将有助于加深人们对LABEPS的认识,并从LABEPS中开发新的活性药物。虽然研究成果相对丰富,低产量,复杂结构,和EPS的临床试验仍然是阻碍其发展的原因。因此,未来的知识扩张应该集中在结构的调节上,物理化学性质,函数,更高的EPS产量,和临床试验应用,这可以进一步提高EPS的商业意义和价值。此外,迄今为止,更好地理解食品中EPS的结构-功能关系仍然是一个挑战。
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