UNASSIGNED: A systematic review and network meta-analysis (NMA) was conducted on randomized controlled trials investigating the efficacy of immunosuppressant-induced therapy for LN. The random effects model was used in the analysis. I2 was used to evaluate the heterogeneity of the model. Odds ratios (OR) and 95% credible intervals (CrI) were computed to assess and compare the relative effectiveness and safety of various treatment protocols.
UNASSIGNED: The study included a total of 16 randomized controlled trials (RCTs) involving 2444 patients with LN. The analysis results indicated that there was no significant difference in terms of partial remission (PR) between the drugs. However, when considering complete remission (CR), the combination of Voclosporin with MMF showed the highest remission rate, followed by Tacrolimus (TAC). Unfortunately, Voclosporin in combination with MMF had the highest risk of infection and serious infection, indicating a lower safety profile.
UNASSIGNED: Voclosporin in combination with MMF demonstrated the highest efficacy as an induction therapy for LN. However, it should be noted that the risk of infection and serious infection was found to be high with this regimen. On the other hand, TAC not only showed efficacy but also had a lower risk of infection and serious infection, making it a favorable option in terms of safety. This study did\' not include results on other adverse events.
■对随机对照试验进行系统评价和网络荟萃分析(NMA),研究免疫抑制剂诱导治疗LN的疗效。分析采用随机效应模型。I2用于评估模型的异质性。计算赔率比(OR)和95%可信间隔(CrI)以评估和比较各种治疗方案的相对有效性和安全性。
■该研究共包括16项随机对照试验(RCT),涉及2444例LN患者。分析结果表明,药物之间在部分缓解(PR)方面没有显着差异。然而,当考虑完全缓解(CR)时,Voclosporin与MMF的组合显示出最高的缓解率,其次是他克莫司(TAC)。不幸的是,Voclosporin与MMF联合感染和严重感染的风险最高,表明安全性较低。
■Voclosporin与MMF组合显示出作为LN的诱导疗法的最高功效。然而,应该注意的是,该方案发现感染和严重感染的风险很高。另一方面,TAC不仅显示出疗效,而且具有较低的感染和严重感染的风险,使其成为安全方面的有利选择。本研究不包括其他不良事件的结果。