PDF(Pubmed)
Abstract：
The adverse effects of exposure to fine particulate matter (PM2.5) on body health have attracted global public attention. However, there is limited research on PM2.5 in animal houses. Numerous studies have indicated that long-term exposure to high levels of PM2.5 can cause damage to multiple systems in animals. Poultry houses are one of the primary sources of PM2.5 emissions. However, there is limited research on the effects of PM2.5 exposure on poultry organisms. This study analyzed the histopathological changes in the lung tissue of poultry under PM2.5 exposure conditions. It used the LC-MS method to analyze the alterations in the serum metabolomic profile of poultry. This study confirmed that long-term exposure to high levels of PM2.5 had significantly reduced the growth performance of poultry. Histopathological slides of the lung tissue in chickens exposed to long-term retention of PM2.5 clearly showed significant damage. Furthermore, the serum metabolome analysis revealed significant changes in the serum metabolic profile of chickens exposed to long-term PM2.5 exposure. Specifically, there were notable alterations in the Glycerophospholipid metabolism, Steroid hormone biosynthesis, and Phenylalanine, tyrosine, and tryptophan biosynthesis pathways.
摘要：
细颗粒物（PM2.5）暴露对身体健康的不利影响已引起全球公众的关注。然而,对动物屋中PM2.5的研究有限。许多研究表明，长期暴露于高水平的PM2.5会对动物的多个系统造成损害。禽舍是PM2.5排放的主要来源之一。然而,关于PM2.5暴露对家禽生物的影响的研究有限。本研究分析了PM2.5暴露条件下家禽肺组织的组织病理学变化。它使用LC-MS方法来分析家禽血清代谢组学谱的变化。这项研究证实，长期暴露于高水平的PM2.5会显著降低家禽的生长性能。长期暴露于PM2.5的鸡肺组织的组织病理学切片清楚地显示出明显的损伤。此外，血清代谢组分析显示,长期暴露于PM2.5的鸡血清代谢谱发生显著变化.具体来说,甘油磷脂代谢有明显的改变，类固醇激素生物合成，和苯丙氨酸,酪氨酸,和色氨酸生物合成途径。
