PDF(Pubmed)
Abstract：
UNASSIGNED: Primary cystic duct carcinoma, an uncommon and aggressive biliary cancer variant, poses a significant challenge in clinical practice. This study examines recent clinical cases, focusing on diagnostics, interventions, and implications in managing this disease, with a prevalence ranging from 0.03 % to 0.05 %, contributing to 2.6-12.6 % of extrahepatic biliary neoplasms.
METHODS: A 57-year-old male, a smoker with hypertension and hyperuricemia, presented symptoms of severe upper right abdominal pain, jaundice, and altered stool color. Diagnosis revealed ulcerated papillary adenocarcinoma invading all gallbladder layers (2.5 cm). Surgical resection and Roux-en-Y anastomosis were performed. Histopathological examination showed invasive tumor proliferation, preserved lymph node architecture, and severe hepatic microsteatosis. Lymph nodes were tumor-free, and a benign hepatic biopsy (0.5 cm) displayed chronic portitis. The final diagnosis confirmed cystic duct carcinoma, emphasizing the complex diagnostic and therapeutic aspects in biliary cases.
UNASSIGNED: The clinical discussion unveils the complexities associated with primary cystic duct carcinomas. Emphasizing the necessity of a multidisciplinary approach, this case highlights the importance of efficient management strategies-from initial diagnosis to surgical intervention-in dealing with this challenging malignancy.
CONCLUSIONS: In conclusion, this case underscores the intricate nature of primary cystic duct carcinomas. It accentuates the essential role of a multidisciplinary approach, urging the need for continuous research endeavors to further comprehend and enhance the treatment methodologies for this rare and complex malignancy.
METHODS: A 57-year-old male, a smoker with hypertension and hyperuricemia, presented symptoms of severe upper right abdominal pain, jaundice, and altered stool color. Diagnosis revealed ulcerated papillary adenocarcinoma invading all gallbladder layers (2.5 cm). Surgical resection and Roux-en-Y anastomosis were performed. Histopathological examination showed invasive tumor proliferation, preserved lymph node architecture, and severe hepatic microsteatosis. Lymph nodes were tumor-free, and a benign hepatic biopsy (0.5 cm) displayed chronic portitis. The final diagnosis confirmed cystic duct carcinoma, emphasizing the complex diagnostic and therapeutic aspects in biliary cases.
UNASSIGNED: The clinical discussion unveils the complexities associated with primary cystic duct carcinomas. Emphasizing the necessity of a multidisciplinary approach, this case highlights the importance of efficient management strategies-from initial diagnosis to surgical intervention-in dealing with this challenging malignancy.
CONCLUSIONS: In conclusion, this case underscores the intricate nature of primary cystic duct carcinomas. It accentuates the essential role of a multidisciplinary approach, urging the need for continuous research endeavors to further comprehend and enhance the treatment methodologies for this rare and complex malignancy.
摘要：
■原发性胆囊管癌，一种罕见且侵袭性的胆道癌变种，在临床实践中提出了重大挑战。这项研究检查了最近的临床病例，专注于诊断，干预措施，以及控制这种疾病的意义，患病率从0.03%到0.05%不等，导致2.6-12.6％的肝外胆道肿瘤。
方法：一位57岁的男性，患有高血压和高尿酸血症的吸烟者,出现严重右上腹痛的症状，黄疸,改变了大便的颜色.诊断显示溃疡性乳头状腺癌侵犯所有胆囊层（2.5cm）。行手术切除和Roux-en-Y吻合术。组织病理学检查显示侵袭性肿瘤增殖，保留的淋巴结结构，和严重的肝脏微脂肪变性.淋巴结无肿瘤，和良性肝活检（0.5厘米）显示慢性口炎。最终诊断为胆囊管癌，强调胆道病例的复杂诊断和治疗方面。
■临床讨论揭示了原发性胆囊管癌的复杂性。强调多学科方法的必要性，该病例强调了从初始诊断到手术干预的有效治疗策略在处理这种具有挑战性的恶性肿瘤中的重要性.
结论：结论：该病例强调了原发性胆囊管癌的复杂性。它强调了多学科方法的重要作用，敦促需要不断的研究努力，以进一步理解和加强这种罕见和复杂的恶性肿瘤的治疗方法。
方法：一位57岁的男性，患有高血压和高尿酸血症的吸烟者,出现严重右上腹痛的症状，黄疸,改变了大便的颜色.诊断显示溃疡性乳头状腺癌侵犯所有胆囊层（2.5cm）。行手术切除和Roux-en-Y吻合术。组织病理学检查显示侵袭性肿瘤增殖，保留的淋巴结结构，和严重的肝脏微脂肪变性.淋巴结无肿瘤，和良性肝活检（0.5厘米）显示慢性口炎。最终诊断为胆囊管癌，强调胆道病例的复杂诊断和治疗方面。
■临床讨论揭示了原发性胆囊管癌的复杂性。强调多学科方法的必要性，该病例强调了从初始诊断到手术干预的有效治疗策略在处理这种具有挑战性的恶性肿瘤中的重要性.
结论：结论：该病例强调了原发性胆囊管癌的复杂性。它强调了多学科方法的重要作用，敦促需要不断的研究努力，以进一步理解和加强这种罕见和复杂的恶性肿瘤的治疗方法。
