Abstract：
High Frequency Oscillations (HFO) have been found very useful in refractory epilepsy. They have been used to identify the epileptogenic zone and as a promising clinical biomarker for presurgical evaluation in childhood epilepsy. There is controversy about whether there is a spread of HFOs and their propagation. Some researchers reinforce the idea of dealing with epilepsy as a network disorder, so the fact of propagation can promote this research. The hypothesis of this study is that connectivity methods can be useful to detect the seizure onset and propagation zones. Methodology has been applied to two cases where the clinical outcomes after surgery were free of seizures and not free. Promising results were obtained to understand both situations. A future study with more cases is necessary to obtain strong conclusions.Clinical Relevance- This exploratory study shows the relationship between connectivity measures and the propagation of HFOs and this can be useful to know the epileptogenic function of these waves that, nowadays, are unknown. Connectivity features in conjunction with other multivariate estimators can be a tool to help in identifying the regions of interest in refractory epilepsy.
摘要：
已发现高频振荡（HFO）在难治性癫痫中非常有用。它们已被用于鉴定癫痫发生区，并作为儿童癫痫术前评估的有希望的临床生物标志物。关于HFOs的传播及其传播是否存在争议。一些研究人员强化了将癫痫作为一种网络障碍来处理的想法，因此，传播的事实可以促进这项研究。这项研究的假设是，连通性方法可以用于检测癫痫发作和传播区域。方法学已应用于2例手术后的临床结果没有癫痫发作且没有癫痫发作的病例。获得了有希望的结果，以了解这两种情况。未来有必要进行更多案例的研究，以获得强有力的结论。临床相关性-这项探索性研究显示了连通性测量与HFOs传播之间的关系，这对于了解这些波的癫痫功能是有用的，如今,是未知的。与其他多变量估计器结合的连接性特征可以是帮助识别难治性癫痫中的感兴趣区域的工具。
