PDF(Pubmed)
Abstract：
Abnormal findings on optical coherence tomography (OCT) and electroretinography (ERG) have been reported in participants with schizophrenia spectrum disorders (SSDs). This study aims to reveal the pooled standard mean difference (SMD) in retinal parameters on OCT and ERG among participants with SSDs and healthy controls and their association with demographic characteristics, clinical symptoms, smoking, diabetes mellitus, and hypertension.
Using PubMed, Scopus, Web of Science, and PSYNDEX, we searched the literature from inception to March 31, 2023, using specific search terms. This study was registered with PROSPERO (CRD4202235795) and conducted according to PRISMA 2020.
We included 65 studies in the systematic review and 44 in the meta-analysis. Participants with SSDs showed thinning of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer- inner plexiform cell layer, and retinal thickness in all other segments of the macula. A meta-analysis of studies that excluded SSD participants with diabetes and hypertension showed no change in results, except for pRNFL inferior and nasal thickness. Furthermore, a significant difference was found in the pooled SMD of pRNFL temporal thickness between the left and right eyes. Meta-regression analysis revealed an association between retinal thinning and duration of illness, positive and negative symptoms. In OCT angiography, no differences were found in the foveal avascular zone and superficial layer foveal vessel density between SSD participants and controls. In flash ERG, the meta-analysis showed reduced amplitude of both a- and b-waves under photopic and scotopic conditions in SSD participants. Furthermore, the latency of photopic a-wave was significantly shorter in SSD participants in comparison with HCs.
Considering the prior report of retinal thinning in unaffected first-degree relatives and the results of the meta-analysis, the findings suggest that retinal changes in SSDs have both trait and state aspects. Future longitudinal multimodal retinal imaging studies are needed to clarify the pathophysiological mechanisms of these changes and to clarify their utility in individual patient monitoring efforts.
Using PubMed, Scopus, Web of Science, and PSYNDEX, we searched the literature from inception to March 31, 2023, using specific search terms. This study was registered with PROSPERO (CRD4202235795) and conducted according to PRISMA 2020.
We included 65 studies in the systematic review and 44 in the meta-analysis. Participants with SSDs showed thinning of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer- inner plexiform cell layer, and retinal thickness in all other segments of the macula. A meta-analysis of studies that excluded SSD participants with diabetes and hypertension showed no change in results, except for pRNFL inferior and nasal thickness. Furthermore, a significant difference was found in the pooled SMD of pRNFL temporal thickness between the left and right eyes. Meta-regression analysis revealed an association between retinal thinning and duration of illness, positive and negative symptoms. In OCT angiography, no differences were found in the foveal avascular zone and superficial layer foveal vessel density between SSD participants and controls. In flash ERG, the meta-analysis showed reduced amplitude of both a- and b-waves under photopic and scotopic conditions in SSD participants. Furthermore, the latency of photopic a-wave was significantly shorter in SSD participants in comparison with HCs.
Considering the prior report of retinal thinning in unaffected first-degree relatives and the results of the meta-analysis, the findings suggest that retinal changes in SSDs have both trait and state aspects. Future longitudinal multimodal retinal imaging studies are needed to clarify the pathophysiological mechanisms of these changes and to clarify their utility in individual patient monitoring efforts.
摘要：
背景：已经报道了精神分裂症谱系障碍（SSD）参与者的光学相干断层扫描（OCT）和视网膜电图（ERG）的异常发现。本研究旨在揭示SSD患者和健康对照者的OCT和ERG视网膜参数的汇总标准平均差（SMD）及其与人口统计学特征的关系。临床症状,吸烟,糖尿病,和高血压。
方法：使用PubMed，Scopus,WebofScience,和PSYNDEX,我们使用特定的搜索词搜索了从开始到2023年3月31日的文献。本研究已在PROSPERO（CRD4202235795）注册，并根据PRISMA2020进行。
结果：我们在系统评价中纳入了65项研究，在荟萃分析中纳入了44项研究。使用SSD的参与者显示乳头周围视网膜神经纤维层（pRNFL）变薄，黄斑神经节细胞层-内丛状细胞层，和黄斑其他部分的视网膜厚度。对排除患有糖尿病和高血压的SSD参与者的研究进行的荟萃分析显示，结果没有变化。除了pRNFL下壁和鼻部厚度。此外，在左眼和右眼pRNFL颞部厚度的合并SMD中发现了显着差异。荟萃回归分析显示视网膜变薄与疾病持续时间之间存在关联，阳性和阴性症状。在OCT血管造影术中,SSD参与者和对照组的中央凹无血管区和浅层中央凹血管密度没有差异.在FlashERG中，荟萃分析显示,SSD参与者在明视和暗视条件下a波和b波振幅均降低.此外，与HC相比,SSD参与者的明视a波潜伏期明显较短.
结论：考虑到先前关于未受影响的一级亲属视网膜变薄的报道和荟萃分析的结果，研究结果表明，SSD的视网膜变化具有特征和状态两个方面。需要进行未来的纵向多模态视网膜成像研究，以阐明这些变化的病理生理机制，并阐明其在个体患者监测工作中的实用性。
方法：使用PubMed，Scopus,WebofScience,和PSYNDEX,我们使用特定的搜索词搜索了从开始到2023年3月31日的文献。本研究已在PROSPERO（CRD4202235795）注册，并根据PRISMA2020进行。
结果：我们在系统评价中纳入了65项研究，在荟萃分析中纳入了44项研究。使用SSD的参与者显示乳头周围视网膜神经纤维层（pRNFL）变薄，黄斑神经节细胞层-内丛状细胞层，和黄斑其他部分的视网膜厚度。对排除患有糖尿病和高血压的SSD参与者的研究进行的荟萃分析显示，结果没有变化。除了pRNFL下壁和鼻部厚度。此外，在左眼和右眼pRNFL颞部厚度的合并SMD中发现了显着差异。荟萃回归分析显示视网膜变薄与疾病持续时间之间存在关联，阳性和阴性症状。在OCT血管造影术中,SSD参与者和对照组的中央凹无血管区和浅层中央凹血管密度没有差异.在FlashERG中，荟萃分析显示,SSD参与者在明视和暗视条件下a波和b波振幅均降低.此外，与HC相比,SSD参与者的明视a波潜伏期明显较短.
结论：考虑到先前关于未受影响的一级亲属视网膜变薄的报道和荟萃分析的结果，研究结果表明，SSD的视网膜变化具有特征和状态两个方面。需要进行未来的纵向多模态视网膜成像研究，以阐明这些变化的病理生理机制，并阐明其在个体患者监测工作中的实用性。
