Abstract：
UNASSIGNED: We evaluate the efficacy and safety profiles of currently available conservative management options for penile and urethral lichen sclerosus.
UNASSIGNED: A systematic review of existing literature on lichen sclerosus was conducted utilizing the PubMed, Embase, and Web of Science databases. References were assessed for relevance to nonsurgical management of male genital lichen sclerosus by title and abstract by 3 independent reviewers, then reviewed in full and in duplicate by 5 independent reviewers.
UNASSIGNED: Seventeen studies describing conservative management of histologically confirmed penile and urethral lichen sclerosus in male patients were included in the final review. We present available evidence supporting the use of 4 major treatment modalities represented in the existing literature: topical corticosteroids, tacrolimus, platelet-rich plasma, and CO2 laser. We also briefly discuss the limited studies on the use of oral acitretin and polydeoxyribonucleotide injections. Outcomes assessed include symptoms, clinical appearance, quality of life, sexual satisfaction, adverse effects, and long-term efficacy of treatment.
UNASSIGNED: Topical corticosteroids remain the mainstay of conservative management of penile and urethral lichen sclerosus, with current literature supporting the use of other therapies such as tacrolimus and platelet-rich plasma as alternatives or adjuvant treatments when escalation of treatment is necessary. Future research should further explore the efficacy and safety of newer therapies through additional controlled clinical trials in the targeted population.
UNASSIGNED: A systematic review of existing literature on lichen sclerosus was conducted utilizing the PubMed, Embase, and Web of Science databases. References were assessed for relevance to nonsurgical management of male genital lichen sclerosus by title and abstract by 3 independent reviewers, then reviewed in full and in duplicate by 5 independent reviewers.
UNASSIGNED: Seventeen studies describing conservative management of histologically confirmed penile and urethral lichen sclerosus in male patients were included in the final review. We present available evidence supporting the use of 4 major treatment modalities represented in the existing literature: topical corticosteroids, tacrolimus, platelet-rich plasma, and CO2 laser. We also briefly discuss the limited studies on the use of oral acitretin and polydeoxyribonucleotide injections. Outcomes assessed include symptoms, clinical appearance, quality of life, sexual satisfaction, adverse effects, and long-term efficacy of treatment.
UNASSIGNED: Topical corticosteroids remain the mainstay of conservative management of penile and urethral lichen sclerosus, with current literature supporting the use of other therapies such as tacrolimus and platelet-rich plasma as alternatives or adjuvant treatments when escalation of treatment is necessary. Future research should further explore the efficacy and safety of newer therapies through additional controlled clinical trials in the targeted population.
摘要：
■我们评估了目前可用的保守治疗方法对阴茎和尿道硬化性苔藓的疗效和安全性。
■使用PubMed对现有关于硬化性苔藓的文献进行了系统的回顾，Embase,和WebofScience数据库。由3名独立审稿人通过标题和摘要评估了与男性生殖器硬化性苔藓非手术治疗的相关性。然后由5名独立审稿人进行完整和一式两份的审查。
■17项研究描述了男性患者经组织学证实的阴茎和尿道硬化性苔藓的保守治疗。我们提供了现有证据支持使用现有文献中代表的4种主要治疗方式：局部皮质类固醇，他克莫司,富血小板血浆,CO2激光我们还简要讨论了关于口服阿维A和多脱氧核糖核苷酸注射的有限研究。评估的结果包括症状，临床表现，生活质量,性满意度,不利影响，和长期疗效的治疗。
■外用皮质类固醇仍然是保守治疗阴茎和尿道硬化性苔藓的主要手段，目前的文献支持在需要升级治疗时使用他克莫司和富血小板血浆等其他疗法作为替代或辅助治疗。未来的研究应通过在目标人群中进行其他对照临床试验，进一步探索新疗法的有效性和安全性。
■使用PubMed对现有关于硬化性苔藓的文献进行了系统的回顾，Embase,和WebofScience数据库。由3名独立审稿人通过标题和摘要评估了与男性生殖器硬化性苔藓非手术治疗的相关性。然后由5名独立审稿人进行完整和一式两份的审查。
■17项研究描述了男性患者经组织学证实的阴茎和尿道硬化性苔藓的保守治疗。我们提供了现有证据支持使用现有文献中代表的4种主要治疗方式：局部皮质类固醇，他克莫司,富血小板血浆,CO2激光我们还简要讨论了关于口服阿维A和多脱氧核糖核苷酸注射的有限研究。评估的结果包括症状，临床表现，生活质量,性满意度,不利影响，和长期疗效的治疗。
■外用皮质类固醇仍然是保守治疗阴茎和尿道硬化性苔藓的主要手段，目前的文献支持在需要升级治疗时使用他克莫司和富血小板血浆等其他疗法作为替代或辅助治疗。未来的研究应通过在目标人群中进行其他对照临床试验，进一步探索新疗法的有效性和安全性。
