PDF(Pubmed)
Abstract：
Herpes simplex virus type 1 (HSV-1) has been known as a common viral pathogen that can infect several parts of the body, leading to various clinical manifestations. According to this diverse manifestation, HSV-1 infection in many cell types was demonstrated. Besides the HSV-1 cell tropism, e.g., fibroblast, epithelial, mucosal cells, and neurons, HSV-1 infections can occur in human T lymphocyte cells, especially in activated T cells. In addition, several studies found that actin polymerization and filopodia formation support HSV-1 infection in diverse cell types. Hence, the goal of this review is to explore the mechanism of HSV-1 infection in various types of cells involving filopodia formation and highlight potential future directions for HSV-1 entry-related research. Moreover, this review covers several strategies for possible anti-HSV drugs focused on the entry step, offering insights into potential therapeutic interventions.
摘要：
单纯疱疹病毒1型（HSV-1）被认为是一种常见的病毒病原体，可以感染身体的多个部位，导致各种临床表现。根据这种多样化的表现，证明了许多细胞类型中的HSV-1感染。除了HSV-1细胞嗜性,例如，成纤维细胞,上皮，粘膜细胞，和神经元，HSV-1感染可发生在人类T淋巴细胞中，特别是在活化的T细胞中。此外,一些研究发现，肌动蛋白聚合和丝足形成支持不同细胞类型的HSV-1感染。因此，这篇综述的目的是探讨HSV-1感染涉及丝状伪足形成的各种类型细胞的机制，并强调HSV-1进入相关研究的潜在未来方向。此外，这篇综述涵盖了几种可能的抗HSV药物的策略，重点是进入步骤，提供潜在治疗干预措施的见解。
