Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines.

SPBN GASGAS 在口服疫苗接种的狗中诱导的长期免疫不劣于灭活狂犬病疫苗。

• 发表时间: 2023 Dec
• 来源期刊: Vaccine X
• DOI: 10.1016/j.jvacx.2023.100410
• PMID: 38075432
• 文章类型: Journal Article
• 作者列表: Vos A,Kasemsuwan S,Leelahapongsathon K,Bobe K,Perez-Bravo D,Kliemt J,Phawaphutayanchi P,Aiyara N,Freuling CM,Müller T

关键词: DOI; Dog; Efficacy; Immunobridging; Oral vaccination; SPBN GASGAS

Abstract

In a long-term immunogenicity study (1100 days post vaccination) in local Thai dogs the immune response of the oral rabies vaccine SPBN GASGAS was compared to those elicited by a commercial inactivated vaccine using immunobridging. Based on the detection of rabies virus binding (rVBA) and rabies virus neutralizing antibodies (rVNA) as measured by ELISA and Rapid Fluorescent Focus Inhibition Test (RFFIT) the long-term immune response in dogs vaccinated orally with the SPBNA GASGAS strain of rabies vaccine in a bait was non-inferior to a conventional inactivated rabies vaccine. The outcome of this study supports extending the originally claimed duration of immunity (DOI) of SPBN GASGAS after oral vaccination for dogs from 6 to 30 months.

摘要

在当地泰国犬的长期免疫原性研究（疫苗接种后1100天）中，将口服狂犬病疫苗SPBNGASGAS的免疫反应与使用免疫印迹的商业灭活疫苗引起的免疫反应进行了比较。基于通过ELISA和快速荧光聚焦抑制试验(RFFIT)测量的狂犬病病毒结合(rVBA)和狂犬病病毒中和抗体(rVNA)的检测,在诱饵中口服狂犬病疫苗的SPBNAGASGAS株疫苗疫苗的犬中的长期免疫应答不劣于常规灭活狂犬病疫苗。这项研究的结果支持将最初声称的SPBNGASGAS在狗口服疫苗接种后的免疫持续时间(DOI)从6个月延长至30个月。