PDF(Pubmed)
Abstract：
BACKGROUND: Pregnancy after liver transplantation poses a significant challenge to both the patient and the transplant team.
METHODS: We present the case of a 19-year-old European patient who underwent liver transplantation 5 years previously owing to autoimmune hepatitis. Poor compliance with immunosuppressive therapy and missed follow-up visits during the patient\'s first pregnancy likely contributed to her liver function deterioration, hospitalization, and failed pregnancy. Owing to the patient\'s complex medical history, combined immunosuppressive treatment, and risks to the fetus, her second pregnancy was high risk. However, close outpatient monitoring and adherence to treatment led to a successful, uneventful, full-term pregnancy and healthy delivery.
CONCLUSIONS: Liver transplant recipients who desire to become pregnant require careful planning and management to ensure optimal outcomes for both the mother and the fetus. A personalized strategy is necessary to balance the potential benefits of childbirth with the risks involved in pregnancy after liver transplantation.
METHODS: We present the case of a 19-year-old European patient who underwent liver transplantation 5 years previously owing to autoimmune hepatitis. Poor compliance with immunosuppressive therapy and missed follow-up visits during the patient\'s first pregnancy likely contributed to her liver function deterioration, hospitalization, and failed pregnancy. Owing to the patient\'s complex medical history, combined immunosuppressive treatment, and risks to the fetus, her second pregnancy was high risk. However, close outpatient monitoring and adherence to treatment led to a successful, uneventful, full-term pregnancy and healthy delivery.
CONCLUSIONS: Liver transplant recipients who desire to become pregnant require careful planning and management to ensure optimal outcomes for both the mother and the fetus. A personalized strategy is necessary to balance the potential benefits of childbirth with the risks involved in pregnancy after liver transplantation.
摘要：
背景：肝移植后的妊娠对患者和移植团队都构成了重大挑战。
方法：我们介绍了一名19岁的欧洲患者，该患者在5年前因自身免疫性肝炎接受了肝移植。患者首次妊娠期间对免疫抑制治疗的依从性差和错过随访可能导致肝功能恶化。住院治疗,怀孕失败。由于患者的复杂病史，联合免疫抑制治疗，和胎儿的风险，她第二次怀孕的风险很高。然而,密切的门诊监测和对治疗的坚持导致了成功的，平安无事,足月妊娠和健康分娩。
结论：希望怀孕的肝移植受者需要仔细的计划和管理，以确保母亲和胎儿的最佳结局。有必要采取个性化策略来平衡肝移植后分娩的潜在益处与妊娠风险。
方法：我们介绍了一名19岁的欧洲患者，该患者在5年前因自身免疫性肝炎接受了肝移植。患者首次妊娠期间对免疫抑制治疗的依从性差和错过随访可能导致肝功能恶化。住院治疗,怀孕失败。由于患者的复杂病史，联合免疫抑制治疗，和胎儿的风险，她第二次怀孕的风险很高。然而,密切的门诊监测和对治疗的坚持导致了成功的，平安无事,足月妊娠和健康分娩。
结论：希望怀孕的肝移植受者需要仔细的计划和管理，以确保母亲和胎儿的最佳结局。有必要采取个性化策略来平衡肝移植后分娩的潜在益处与妊娠风险。
