Abstract：
Piezoelectric stimulation can have a significant impact on different cellular functions with possible applications in several fields, such as regenerative medicine, cancer therapy, and immunoregulation. For example, piezoelectric stimulation has been shown to modulate cytoskeleton variations: the implications of this effect range from the regulation of migration and invasion of cancer cells to the activation of pro- or anti-inflammatory phenotypes in immune cells. In this chapter, we will present different methodologies to evaluate cytoskeleton variations, focusing on modifications on f-/g-actin ratio and on the migration and invasion ability of tumor cells.
摘要：
压电刺激可以对不同的细胞功能产生重大影响，可能应用于多个领域。比如再生医学，癌症治疗,和免疫调节。例如,压电刺激已被证明可以调节细胞骨架变异:这种效应的影响范围从调节癌细胞的迁移和侵袭到激活免疫细胞中的促炎或抗炎表型.在这一章中,我们将提出不同的方法来评估细胞骨架的变化，重点研究f-/g-肌动蛋白比值的改变以及肿瘤细胞的迁移和侵袭能力。
