PDF(Pubmed)
Abstract：
Zn2+-dependent histone deacetylases (HDACs) are enzymes that regulate gene expression by removing acetyl groups from histone proteins. These enzymes are essential in all living systems, playing key roles in cancer treatment and as potential pesticide targets. Previous phylogenetic analyses of HDAC in certain species have been published. However, their classification and evolutionary origins across biological kingdoms remain unclear, which limits our understanding of them. In this study, we collected the HDAC sequences from 1451 organisms and performed analyses. The HDACs are found to diverge into three classes and seven subclasses under divergent selection pressure. Most subclasses show species specificity, indicating that HDACs have evolved with high plasticity and diversification to adapt to different environmental conditions in different species. In contrast, HDAC1 and HDAC3, belonging to the oldest class, are conserved and crucial in major kingdoms of life, especially HDAC1. These findings lay the groundwork for the future application of HDACs.
摘要：
Zn2+依赖性组蛋白脱乙酰酶(HDAC)是通过从组蛋白中去除乙酰基来调节基因表达的酶。这些酶在所有生命系统中都是必不可少的，在癌症治疗中发挥关键作用，并作为潜在的农药靶标。先前已经发表了某些物种中HDAC的系统发育分析。然而,它们在生物王国中的分类和进化起源仍不清楚，这限制了我们对它们的理解。在这项研究中,我们收集了1451个生物体的HDAC序列并进行了分析.在不同的选择压力下，HDAC分为三类和七个子类。大多数亚类显示出物种特异性，表明HDAC具有高度的可塑性和多样性，以适应不同物种的不同环境条件。相比之下,HDAC1和HDAC3，属于最古老的一类，在生活的主要王国中都是保守和至关重要的，尤其是HDAC1。这些发现为HDAC的未来应用奠定了基础。
