Human Papillomavirus Infection in Penile Cancer: Multidimensional Mechanisms and Vaccine Strategies.

阴茎癌中的人乳头瘤病毒感染 ： 多维机制和疫苗策略。

• 影响指数: 6.208
• 发表时间: 2023 Nov 27
• 来源期刊: Int J Mol Sci
• DOI: 10.3390/ijms242316808
• PMID: 38069131
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 生物
• 作者列表: Wei L,Huang K,Han H,Liu RY

关键词: epigenetics; gene alteration; genome integration; human papillomavirus; immune microenvironment; penile cancer; vaccine

Mesh: Humans; Male; Female; Papillomavirus Infections / complications prevention & control genetics; Penile Neoplasms / prevention & control genetics; Epigenesis, Genetic; Carcinogenesis / genetics; Papillomavirus Vaccines / therapeutic use; Papillomaviridae / genetics; Tumor Microenvironment

Abstract

Penile cancer (PC) is a rare male malignant tumor, with early lymph node metastasis and poor prognosis. Human papillomavirus (HPV) plays a key role in the carcinogenesis of PC. This review aims to summarize the association between HPV infection and PC in terms of virus-host genome integration patterns (the disrupted regions in the HPV and PC genome), genetic alterations, and epigenetic regulation (methylation and microRNA modification) occurring in HPV and PC DNA, as well as tumor immune microenvironment reprogramming. In addition, the potential of HPV vaccination strategies for PC prevention and treatment is discussed. Understanding of the HPV-related multidimensional mechanisms and the application of HPV vaccines will promote rational and novel management of PC.

摘要

阴茎癌（PC）是一种罕见的男性恶性肿瘤，伴早期淋巴结转移，预后差。人乳头瘤病毒（HPV）在PC的癌变中起关键作用。这篇综述旨在总结HPV感染与PC之间在病毒-宿主基因组整合模式（HPV和PC基因组中的破坏区域）方面的关联。遗传改变,和表观遗传调控（甲基化和microRNA修饰）发生在HPV和PCDNA，以及肿瘤免疫微环境重编程。此外,讨论了HPV疫苗接种策略在PC预防和治疗中的潜力.了解HPV相关的多维机制和HPV疫苗的应用将促进PC的合理和新颖管理。