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Abstract：
This prospective study aimed to evaluate inflammatory status in cats affected by chronic kidney disease (CKD) at IRIS stages 2-4, using serum amyloid A (SAA) and the erythrocyte sedimentation rate (ESR) as inflammatory markers. Thirty-two cats with CKD and ten clinically healthy cats (i.e., control group) were enrolled. The recording of signalment data, complete physical examinations, and abdominal ultrasonography were performed for each animal. Additionally, ESR levels, complete blood count, clinical chemistry (including SAA determination), serum protein electrophoresis, and complete urinalysis were executed. This study\'s results showed that mean ESR and SAA concentrations in cats with CKD were statistically higher compared to those of the control group (p = 0.0005 and p = 0.007, respectively). The SAA concentration was significantly increased at IRIS stages 2, 3, and 4 compared to the control group. Meanwhile, the ESR was significantly higher in cats at IRIS stages 3 and 4 (p = 0.0003 and p = 0.0007, respectively), but not at IRIS stage 2, compared to the control group. These results provide evidence that feline CKD is associated with a systemic inflammatory status. Moreover, the rise in ESR appears to be more linked to advanced stages of the disease and could, therefore, correlate with the uremic condition.
摘要：
这项前瞻性研究旨在使用血清淀粉样蛋白A（SAA）和红细胞沉降率（ESR）作为炎症标志物，评估在IRIS2-4期受慢性肾脏疾病（CKD）影响的猫的炎症状态。32只患有CKD的猫和10只临床健康的猫(即，对照组)。标志数据的记录，完成身体检查，对每只动物进行腹部超声检查。此外,ESR水平,全血细胞计数,临床化学（包括SAA测定），血清蛋白电泳,并执行了完整的尿液分析。这项研究的结果表明，与对照组相比，CKD猫的平均ESR和SAA浓度在统计学上较高（分别为p=0.0005和p=0.007）。与对照组相比,在IRIS阶段2、3和4,SAA浓度显著增加。同时,在IRIS阶段3和4的猫中ESR明显更高（分别为p=0.0003和p=0.0007），但与对照组相比，在IRIS第2阶段没有。这些结果提供了猫CKD与全身性炎症状态相关的证据。此外，ESR的上升似乎与疾病的晚期阶段更相关，因此,与尿毒症状况有关。
