PDF(Pubmed)
Abstract：
The research aimed to detect the association between single nucleotide polymorphisms (SNPs) in CYP4V2 gene and coronary heart disease (CHD) risk.
This case-control study included 487 CHD subjects and 487 healthy individuals. Logistic regression was performed to analyze the connection between five SNPs in CYP4V2 (rs1398007, rs13146272, rs3736455, rs1053094, and rs56413992) and CHD risk, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the connection.
As a result, we found that rs56413992 T allele (OR = 1.36, 95% CI = 1.09-1.70, p = 0.007) and CT genotype (OR = 1.40, 95% CI = 1.06-1.83, p = 0.017) were significantly associated with an increased risk of CHD in the overall analysis. Precisely, rs56413992 was linked to an elevated risk of CHD in people aged > 60, males, smokers and drinkers. The study also indicated that rs1398007 was linked to an increased CHD risk in drinkers. In addition, rs1053094 was correlated with a decreased risk of CHD complicated with diabetes mellitus (DM), and rs1398007 was correlated with a decreased risk of CHD complicated with hypertension (HTN).
This study was the first to experimentally demonstrate that CYP4V2 rs56413992 was associated with the risk of CHD, which will provide a certain reference for revealing the pathogenesis of CHD.
This case-control study included 487 CHD subjects and 487 healthy individuals. Logistic regression was performed to analyze the connection between five SNPs in CYP4V2 (rs1398007, rs13146272, rs3736455, rs1053094, and rs56413992) and CHD risk, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the connection.
As a result, we found that rs56413992 T allele (OR = 1.36, 95% CI = 1.09-1.70, p = 0.007) and CT genotype (OR = 1.40, 95% CI = 1.06-1.83, p = 0.017) were significantly associated with an increased risk of CHD in the overall analysis. Precisely, rs56413992 was linked to an elevated risk of CHD in people aged > 60, males, smokers and drinkers. The study also indicated that rs1398007 was linked to an increased CHD risk in drinkers. In addition, rs1053094 was correlated with a decreased risk of CHD complicated with diabetes mellitus (DM), and rs1398007 was correlated with a decreased risk of CHD complicated with hypertension (HTN).
This study was the first to experimentally demonstrate that CYP4V2 rs56413992 was associated with the risk of CHD, which will provide a certain reference for revealing the pathogenesis of CHD.
摘要：
目的：本研究旨在检测CYP4V2基因的单核苷酸多态性（SNPs）与冠心病（CHD）风险的相关性。
方法：本病例对照研究包括487名CHD受试者和487名健康个体。进行Logistic回归分析CYP4V2中的五个SNP（rs1398007，rs13146272，rs3736455，rs1053094和rs56413992）与CHD风险之间的关系。计算比值比(OR)和95%置信区间(CIs)以评估连接。
结果：因此，我们发现rs56413992T等位基因(OR=1.36,95%CI=1.09-1.70,p=0.007)和CT基因型(OR=1.40,95%CI=1.06-1.83,p=0.017)在总体分析中与冠心病风险增加显著相关.准确地说，rs56413992与60岁以上男性冠心病风险升高有关，吸烟者和饮酒者。研究还表明，rs1398007与饮酒者冠心病风险增加有关。此外,rs1053094与冠心病合并糖尿病（DM）的风险降低相关，rs1398007与冠心病合并高血压（HTN）的风险降低相关。
结论：这项研究首次通过实验证明CYP4V2rs56413992与冠心病的风险相关，为揭示冠心病的发病机制提供一定的参考。
方法：本病例对照研究包括487名CHD受试者和487名健康个体。进行Logistic回归分析CYP4V2中的五个SNP（rs1398007，rs13146272，rs3736455，rs1053094和rs56413992）与CHD风险之间的关系。计算比值比(OR)和95%置信区间(CIs)以评估连接。
结果：因此，我们发现rs56413992T等位基因(OR=1.36,95%CI=1.09-1.70,p=0.007)和CT基因型(OR=1.40,95%CI=1.06-1.83,p=0.017)在总体分析中与冠心病风险增加显著相关.准确地说，rs56413992与60岁以上男性冠心病风险升高有关，吸烟者和饮酒者。研究还表明，rs1398007与饮酒者冠心病风险增加有关。此外,rs1053094与冠心病合并糖尿病（DM）的风险降低相关，rs1398007与冠心病合并高血压（HTN）的风险降低相关。
结论：这项研究首次通过实验证明CYP4V2rs56413992与冠心病的风险相关，为揭示冠心病的发病机制提供一定的参考。
