Abstract：
Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, both have been associated to a tauopathy mainly affecting the brainstem. Nonetheless, anti-IgLON5 antibodies have never been tested in PAPT. We report on two PAPT cases without evidence of anti-IgLON5 antibodies in both CSF and serum. Despite common clinical and pathological characteristics, PAPT and IgLON5 disease are two distinct entities.
摘要：
进行性共济失调和腭震颤（PAPT）和抗IgLON5疾病具有可能的临床表现。此外，两者都与主要影响脑干的tau蛋白病有关。尽管如此，抗IgLON5抗体从未在PAPT中进行过测试。我们报告了两例PAPT病例，在CSF和血清中均没有抗IgLON5抗体的证据。尽管有共同的临床和病理特征，PAPT和IgLON5疾病是两个不同的实体。
