METHODS: We conducted a prospective case-control study. Cases were arranged into two groups. The postoperative group (POG) included those who underwent unilateral ovarian cystectomy, and those in the benign ovarian cyst group (BOCG) had complex ovarian cysts with a diameter of 5 cm or more. Adolescents without ovarian pathologies were included in the reference group (RFG). Levels of anti-Mullerian hormone (AMH) and follicular stimulating hormone (FSH) were measured, and an ultrasound investigation of antral follicular count (AFC) was also done.
RESULTS: Mean differences between baseline and 6-month follow-up levels of AMH, AFC significantly decreased in both the POG and BOCG compared to the RFG. However, the decrease was more significant in the POG: a decrease of 0.86 ng/mL for AMH and 3.11 ng/mL for AFC versus decreasing by 0.61 ng/mL for AMH and 1.68 ng/mL for AFC. Meanwhile, in the BOCG, 6-month FSH levels did not show any significant changes compared to the baseline measurement. In comparison with the reference group, there was a significant decrease in the levels of AMH and AFC among participants who had endometriomas and cystadenomas.
CONCLUSIONS: Benign ovarian cysts 5 cm or more in diameter, as well as cystectomy, statistically affect OR after 6 months. Therefore, adolescents with ovarian cyst or cystectomy need individualized support to maintain reproductive age fertility.
方法:我们进行了一项前瞻性病例对照研究。将病例分为两组。术后组(POG)包括接受单侧卵巢囊肿切除术的患者,良性卵巢囊肿组(BOCG)有直径5cm以上的复杂卵巢囊肿。没有卵巢病变的青少年包括在参照组(RFG)中。测量抗苗勒管激素(AMH)和卵泡刺激素(FSH)的水平,还进行了腔卵泡计数(AFC)的超声检查。
结果:AMH基线水平和6个月随访水平之间的平均差异,与RFG相比,POG和BOCG中的AFC均显着降低。然而,POG的下降更为显著:AMH下降0.86ng/mL,AFC下降3.11ng/mL,而AMH下降0.61ng/mL,AFC下降1.68ng/mL.同时,在BOCG中,与基线测量相比,6个月FSH水平未显示任何显着变化。与参照组相比,在患有子宫内膜瘤和囊腺瘤的参与者中,AMH和AFC水平显著下降.
结论:良性卵巢囊肿直径5cm以上,以及膀胱切除术,6个月后对OR有统计学影响。因此,患有卵巢囊肿或膀胱切除术的青少年需要个体化支持以维持生育年龄.