Abstract：
BACKGROUND: Trabecular bone score (TBS) is partially independent of fracture risk. Reference values for TBS have not been established in official guidelines, and thus clinicians often have difficulty interpreting TBS results. This study aimed to investigate whether reference values for TBS could be a valid indicator for clinical vertebral fracture (CVF).
METHODS: This cross-sectional study involved 231 women with CVF and 563 women without CVF aged 60-90 years who underwent dual-energy X-ray absorptiometry during 2019-2023. They were divided into osteoporosis, osteopenia, and normal groups according to bone mineral density of the lumbar spine. Reference values for TBS were defined as low (≤ 1.23), intermediate (1.23-1.31), and high (≥ 1.31).
RESULTS: Among patients without anti-osteoporosis treatment (n = 476), the proportion with low TBS was 36.7% in the CVF group and 10.7% in the control group. The proportion with CVF was higher in the low TBS group than in the intermediate and high TBS groups, especially in the osteoporosis group (p < 0.001). The odds ratio for CVF was higher in the low TBS group than in the intermediate and high especially in patients with normal BMD and osteoporosis. The TBS cut-off values for incidence of CVF in the osteoporosis, osteopenia, and normal groups were 1.224, 1.319, and 1.322, respectively.
CONCLUSIONS: The reference value for low TBS (≤ 1.23) was useful as an indicator for CVF, especially in patients with osteoporosis. It is expected that reference values for TBS will be established in official guidelines in the future.
METHODS: This cross-sectional study involved 231 women with CVF and 563 women without CVF aged 60-90 years who underwent dual-energy X-ray absorptiometry during 2019-2023. They were divided into osteoporosis, osteopenia, and normal groups according to bone mineral density of the lumbar spine. Reference values for TBS were defined as low (≤ 1.23), intermediate (1.23-1.31), and high (≥ 1.31).
RESULTS: Among patients without anti-osteoporosis treatment (n = 476), the proportion with low TBS was 36.7% in the CVF group and 10.7% in the control group. The proportion with CVF was higher in the low TBS group than in the intermediate and high TBS groups, especially in the osteoporosis group (p < 0.001). The odds ratio for CVF was higher in the low TBS group than in the intermediate and high especially in patients with normal BMD and osteoporosis. The TBS cut-off values for incidence of CVF in the osteoporosis, osteopenia, and normal groups were 1.224, 1.319, and 1.322, respectively.
CONCLUSIONS: The reference value for low TBS (≤ 1.23) was useful as an indicator for CVF, especially in patients with osteoporosis. It is expected that reference values for TBS will be established in official guidelines in the future.
摘要：
背景：骨小梁评分（TBS）部分独立于骨折风险。官方指南中尚未确定TBS的参考值，因此，临床医生通常难以解释TBS结果。本研究旨在探讨TBS参考值是否可以作为临床椎体骨折（CVF）的有效指标。
方法：这项横断面研究涉及231名患有CVF的女性和563名年龄在60-90岁之间的无CVF的女性，他们在2019-2023年期间接受了双能X射线吸收测定法。它们分为骨质疏松症，骨质减少,根据腰椎的骨密度和正常组。TBS的参考值定义为低（≤1.23），中间（1.23-1.31），和高（≥1.31）。
结果：在没有抗骨质疏松治疗的患者中（n=476），CVF组低TBS的比例为36.7%，对照组为10.7%。低TBS组有CVF的比例高于中、高TBS组,尤其是骨质疏松组(p<0.001)。低TBS组的CVF比值比高于中，高，尤其是正常BMD和骨质疏松症的患者。骨质疏松症中CVF发生率的TBS临界值，骨质减少,和正常组分别为1.224、1.319和1.322。
结论：低TBS（≤1.23）的参考值可用作CVF的指标，尤其是骨质疏松症患者。预计将来将在官方准则中确定TBS的参考值。
方法：这项横断面研究涉及231名患有CVF的女性和563名年龄在60-90岁之间的无CVF的女性，他们在2019-2023年期间接受了双能X射线吸收测定法。它们分为骨质疏松症，骨质减少,根据腰椎的骨密度和正常组。TBS的参考值定义为低（≤1.23），中间（1.23-1.31），和高（≥1.31）。
结果：在没有抗骨质疏松治疗的患者中（n=476），CVF组低TBS的比例为36.7%，对照组为10.7%。低TBS组有CVF的比例高于中、高TBS组,尤其是骨质疏松组(p<0.001)。低TBS组的CVF比值比高于中，高，尤其是正常BMD和骨质疏松症的患者。骨质疏松症中CVF发生率的TBS临界值，骨质减少,和正常组分别为1.224、1.319和1.322。
结论：低TBS（≤1.23）的参考值可用作CVF的指标，尤其是骨质疏松症患者。预计将来将在官方准则中确定TBS的参考值。
