Abstract：
BACKGROUND: Maca root (Lepidium meyenii Walp.) is a Peruvian plant of the Brassicaceae family. Maca roots are popular food supplements used to treat a variety of ailments described traditionally as enhancing metabolic and health conditions.
OBJECTIVE: Metabolic syndrome (MetS) has been the real scourge globally, affecting more than one-fourth of the global population. MetS causes the development of multi-organ illnesses, including altered blood cholesterol and sugar levels, oxidative stress, and hypertension. This study evaluated maca root total methanolic extract (MTE) as a potential nutraceutical to manage the complications of MetS.
METHODS: After the first 4 weeks of a high-fat high-carbohydrate diet (HFCD), streptozotocin (STZ) was injected in Wistar rats to induce the MetS model. Animals were treated orally with MTE at 100 mg/kg and 300 mg/kg for 4 weeks compared to metformin at 200 mg/kg after confirmation of diabetes.
RESULTS: One month of MTE supplementation in HFCD-fed rats remarkably decreased the elevation of blood glucose and lipids, improved liver function and insulin resistance, additionally it successfully restored the state of inflammatory and oxidative stress. The extract was standardized to contain total phenolics equal to 24.45 ± 0.96 μg Gallic acid/mg extract.
CONCLUSIONS: Our findings suggest that MTE improves MetS by reducing hyperglycemia, hyperlipidemia, inflammation, and oxidative stress. While also improving beta cell secretory functions, implying that MTE could be used as a balancing drug in the prevention and treatment of metabolic abnormalities linked to type 2 diabetes.
OBJECTIVE: Metabolic syndrome (MetS) has been the real scourge globally, affecting more than one-fourth of the global population. MetS causes the development of multi-organ illnesses, including altered blood cholesterol and sugar levels, oxidative stress, and hypertension. This study evaluated maca root total methanolic extract (MTE) as a potential nutraceutical to manage the complications of MetS.
METHODS: After the first 4 weeks of a high-fat high-carbohydrate diet (HFCD), streptozotocin (STZ) was injected in Wistar rats to induce the MetS model. Animals were treated orally with MTE at 100 mg/kg and 300 mg/kg for 4 weeks compared to metformin at 200 mg/kg after confirmation of diabetes.
RESULTS: One month of MTE supplementation in HFCD-fed rats remarkably decreased the elevation of blood glucose and lipids, improved liver function and insulin resistance, additionally it successfully restored the state of inflammatory and oxidative stress. The extract was standardized to contain total phenolics equal to 24.45 ± 0.96 μg Gallic acid/mg extract.
CONCLUSIONS: Our findings suggest that MTE improves MetS by reducing hyperglycemia, hyperlipidemia, inflammation, and oxidative stress. While also improving beta cell secretory functions, implying that MTE could be used as a balancing drug in the prevention and treatment of metabolic abnormalities linked to type 2 diabetes.
摘要：
背景：玛卡根（下皮草。）是十字花科的秘鲁植物。玛卡根是流行的食品补充剂，用于治疗传统上描述为增强代谢和健康状况的各种疾病。
目的：代谢综合征（MetS）在全球范围内一直是真正的祸害，影响了全球四分之一以上的人口。MetS导致多器官疾病的发展，包括改变血液胆固醇和血糖水平，氧化应激，和高血压。这项研究评估了玛卡根总甲醇提取物（MTE）作为管理MetS并发症的潜在营养药物。
方法：在高脂高碳水化合物饮食（HFCD）的前4周后，在Wistar大鼠中注射链脲佐菌素(STZ)以诱导MetS模型。在确认糖尿病后,与200mg/kg的二甲双胍相比,用100mg/kg和300mg/kg的MTE口服治疗动物4周。
结果：饲喂HFCD的大鼠补充MTE1个月可显著降低血糖和血脂的升高，改善肝功能和胰岛素抵抗，此外，它成功地恢复了炎症和氧化应激的状态。将提取物标准化为含有等于24.45±0.96μg没食子酸/mg提取物的总酚。
结论：我们的研究结果表明，MTE通过降低高血糖来改善MetS，高脂血症,炎症,和氧化应激。同时也改善β细胞分泌功能，这意味着MTE可以用作预防和治疗与2型糖尿病相关的代谢异常的平衡药物。
目的：代谢综合征（MetS）在全球范围内一直是真正的祸害，影响了全球四分之一以上的人口。MetS导致多器官疾病的发展，包括改变血液胆固醇和血糖水平，氧化应激，和高血压。这项研究评估了玛卡根总甲醇提取物（MTE）作为管理MetS并发症的潜在营养药物。
方法：在高脂高碳水化合物饮食（HFCD）的前4周后，在Wistar大鼠中注射链脲佐菌素(STZ)以诱导MetS模型。在确认糖尿病后,与200mg/kg的二甲双胍相比,用100mg/kg和300mg/kg的MTE口服治疗动物4周。
结果：饲喂HFCD的大鼠补充MTE1个月可显著降低血糖和血脂的升高，改善肝功能和胰岛素抵抗，此外，它成功地恢复了炎症和氧化应激的状态。将提取物标准化为含有等于24.45±0.96μg没食子酸/mg提取物的总酚。
结论：我们的研究结果表明，MTE通过降低高血糖来改善MetS，高脂血症,炎症,和氧化应激。同时也改善β细胞分泌功能，这意味着MTE可以用作预防和治疗与2型糖尿病相关的代谢异常的平衡药物。
