Abstract：
Tension-free abdominal wall hernia patch materials (AWHPMs) play an important role in the repair of abdominal wall defects (AWDs), which have a recurrence rate of <1%. Nevertheless, there are still significant challenges in the development of tailored, biomimetic, and extracellular matrix (ECM)-like AWHPMs that satisfy the clinical demands of abdominal wall repair (AWR) while effectively handling post-operative complications associated with abdominal hernias, such as intra-abdominal visceral adhesion and abnormal healing. This extensive review presents a comprehensive guide to the high-end fabrication and the precise selection of these advanced AWHPMs. The review begins by briefly introducing the structures, sources, and properties of AWHPMs, and critically evaluates the advantages and disadvantages of different types of AWHPMs for AWR applications. The review subsequently summarizes and elaborates upon state-of-the-art AWHPM fabrication methods and their key characteristics (e.g., mechanical, physicochemical, and biological properties in vitro/vivo). This review uses compelling examples to demonstrate that advanced AWHPMs with multiple functionalities (e.g., anti-deformation, anti-inflammation, anti-adhesion, pro-healing properties, etc.) can meet the fundamental clinical demands required to successfully repair AWDs. In particular, there have been several developments in the enhancement of biomimetic AWHPMs with multiple properties, and additional breakthroughs are expected in the near future.
摘要：
无张力腹壁疝补片材料(AWHPMs)在腹壁缺损(AWDs)的修复中起重要作用,复发率低于1%。然而，在定制的发展中仍然存在重大挑战，仿生,和细胞外基质（ECM）样AWHPM，满足腹壁修复（AWR）的临床需求，同时有效处理与腹部疝相关的术后并发症，如腹内内脏粘连和异常愈合。Thisextensivereviewpresentsacomprehensiveguidetothehigh-endfabricationandtheprecisionselectionoftheseadvancedAWHPMs.Webeginbrieflyintroducingthestructures,来源,和AWHPM的属性，并批判性地评估用于AWR应用的不同类型的AWHPM的优缺点。我们随后总结并阐述了最先进的AWHPM制造方法及其关键特征(例如，机械,物理化学,和体外/体内的生物学特性)。这篇评论使用了令人信服的例子来证明具有多种功能的高级AWHM(例如，抗变形，抗炎，防粘连,促愈合特性，等）可以满足成功修复AWD所需的基本临床需求。特别是,在增强具有多种特性的仿生AWHPM方面已经有了一些进展，预计在不久的将来会有更多的突破。本文受版权保护。保留所有权利。
