PDF(Pubmed)
Abstract：
A 26-year-old female was hospitalized with acute lower motor neuron quadriplegia. Laboratory tests pointed to the presence of distal renal tubular acidosis, which was characterized by hyperchloremic metabolic acidosis, severe hypokalemia, alkaline urine, and a positive urinary anion gap. She also had aminoaciduria, hyperphosphaturia, hypophosphatemia, and normoglycemic glycosuria, all of which are indicative of dysfunction of proximal tubules. Further investigation confirmed Sjogren\'s syndrome. Strangely, our patient also experienced carpopedal spasms and had low calcium and magnesium levels. As the hypokalemia, hypocalcemia, and acidosis were corrected, the quadriplegia and carpopedal spasm improved. By the time of discharge, proximal tubular abnormalities were rectified (with the exception of albuminuria). One well-known renal symptom of Sjogren\'s syndrome is distal tubular acidosis. The brief proximal tubular dysfunction and distal tubular acidosis in Sjogren\'s syndrome is rare. This case report highlights a rare renal complication of Sjogren\'s syndrome.
摘要：
一名26岁的女性因急性下运动神经元四肢瘫痪住院。实验室检查显示存在远端肾小管酸中毒,以高氯血症代谢性酸中毒为特征，严重的低钾血症,碱性尿液,和正尿阴离子间隙。她也有氨基酸尿症,高磷尿,低磷酸盐血症,血糖正常的糖尿，所有这些都表明近端小管功能障碍。进一步的调查证实干燥综合征。奇怪的是,我们的患者也经历了肉足痉挛，钙和镁水平低。作为低钾血症，低钙血症,酸中毒得到纠正,四肢瘫痪和腕足痉挛得到改善。到放电的时候，近端肾小管异常得到纠正(白蛋白尿除外).干燥综合征的一个众所周知的肾脏症状是远端管状酸中毒。干燥综合征中短暂的近端管状功能障碍和远端管状酸中毒很少见。此病例报告突出了干燥综合征的罕见肾脏并发症。
