PDF(Pubmed)
Abstract：
OBJECTIVE: This study aimed to evaluate the efficacy and safety of montelukast (Mon) + fluticasone propionate (Flu) versus Flu in the treatment of cough variant asthma (CVA) in children.
METHODS: Eligible documents were selected from various databases. Weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate continuous variables, and categorical variables were evaluated using risk ratio (RR) and 95% CI. Heterogeneity analysis was performed using Cochran\'s Q test and I2 statistics, followed by sensitivity analysis and publication bias evaluation.
RESULTS: Nine studies were included, and Flu + Mon was found to significantly improve the total effective rate and reduce cough recurrence compared to Flu. The cough remission and disappearance times in the Mon + Flu group were significantly lower than those in the Flu group. FEV1% recovery in the Mon + Flu group was significantly better than that in the Flu group.
CONCLUSIONS: Mon + Flu is effective and safe for the treatment of CVA in children.
METHODS: Eligible documents were selected from various databases. Weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate continuous variables, and categorical variables were evaluated using risk ratio (RR) and 95% CI. Heterogeneity analysis was performed using Cochran\'s Q test and I2 statistics, followed by sensitivity analysis and publication bias evaluation.
RESULTS: Nine studies were included, and Flu + Mon was found to significantly improve the total effective rate and reduce cough recurrence compared to Flu. The cough remission and disappearance times in the Mon + Flu group were significantly lower than those in the Flu group. FEV1% recovery in the Mon + Flu group was significantly better than that in the Flu group.
CONCLUSIONS: Mon + Flu is effective and safe for the treatment of CVA in children.
摘要：
目的：本研究旨在评估孟鲁司特（Mon）+丙酸氟替卡松（Flu）与流感治疗儿童咳嗽变异性哮喘（CVA）的疗效和安全性。
方法：从各种数据库中选择合格的文件。加权平均差(WMD)和95%置信区间(CI)用于评估连续变量，和分类变量使用风险比(RR)和95%CI进行评估。异质性分析采用Cochran的Q检验和I2统计量，其次是敏感性分析和发表偏倚评估。
结果：纳入了9项研究，与流感相比，流感+孟能显著提高总有效率，减少咳嗽复发。Mon+Flu组的咳嗽缓解和消失时间明显低于Flu组。Mon+Flu组FEV1%恢复显著优于Flu组。
结论：Mon+Flu治疗儿童CVA是安全有效的。
方法：从各种数据库中选择合格的文件。加权平均差(WMD)和95%置信区间(CI)用于评估连续变量，和分类变量使用风险比(RR)和95%CI进行评估。异质性分析采用Cochran的Q检验和I2统计量，其次是敏感性分析和发表偏倚评估。
结果：纳入了9项研究，与流感相比，流感+孟能显著提高总有效率，减少咳嗽复发。Mon+Flu组的咳嗽缓解和消失时间明显低于Flu组。Mon+Flu组FEV1%恢复显著优于Flu组。
结论：Mon+Flu治疗儿童CVA是安全有效的。
