Abstract：
Rare actinomycetes are highly valued as potential sources of novel bioactive secondary metabolites. Among these rare actinomycetes, the genus Saccharothrix is particularly noteworthy due to its ability to produce a diverse range of bioactive secondary metabolites. With the continuous sequencing of bacterial genomes and the rapid development of bioinformatics technologies, our knowledge of the secondary metabolic potential of Saccharothrix can become more comprehensive, but this space has not been reviewed or explored. This review presents a detailed overview of the chemical structures and bioactivities of 138 Saccharothrix-derived secondary metabolites, which are classified into five distinct groups based on their biosynthetic pathways. Furthermore, we delve into experimentally characterized biosynthetic pathways of nine bioactive metabolites. By utilizing a combination of cheminformatic and bioinformatic approaches, we attempted to establish connections between the metabolite families and the biosynthetic gene cluster families encoded by Saccharothrix strains. Our analysis provides a comprehensive perspective on the secondary metabolites that can be linked to corresponding BGCs and highlights the underexplored biosynthetic potential of Saccharothrix. This review also provides guidance for the targeted discovery and biosynthesis of novel natural products from Saccharothrix.
摘要：
稀有放线菌作为新型生物活性次级代谢产物的潜在来源受到高度重视。在这些罕见的放线菌中，由于其能够产生多种生物活性次级代谢产物，因此特别值得注意。随着细菌基因组测序的不断进行和生物信息学技术的快速发展,我们对蔗糖素的次级代谢潜力的了解可以变得更加全面，但是这个空间还没有被审查或探索过。这篇综述详细介绍了138个糖原衍生的次级代谢产物的化学结构和生物活性，根据其生物合成途径分为五个不同的组。此外，我们深入研究了九种生物活性代谢物的实验表征的生物合成途径。通过利用化学信息学和生物信息学方法的组合，我们试图建立代谢产物家族和由蔗糖菌株编码的生物合成基因簇家族之间的联系。我们的分析提供了可以与相应的BGC相关的次级代谢产物的全面视角，并突出了糖原的未充分开发的生物合成潜力。本综述也为有针对性地发现和生物合成新型糖原天然产物提供了指导。
