OBJECTIVE: The objective of this comprehensive review is to furnish current and exhaustive knowledge pertaining to the pharmacological, phytochemical, and therapeutic properties of Cimicifuga sp.
METHODS: In this review, all the available information was collected on Cimicifugasp. via computerized search using Google Scholar, PubMed, Research Gate, Sci-Hub, supplementary resources (books, government reports, and Ph.D. theses).
RESULTS: The phytochemical investigation on Cimicifuga sp. has shown phytoconstituents such as triterpenoid glycosides, phenylpropanoid, flavonoids, saponin, lignan, nitrogenous compounds, alkaloids, 4α-Methyl steroids and some other component like monoterpene lactones cimicifugolides A-C etc. Cimicifuga conveys a wide scope of research on in-vitro and in-vivo pharmacological potential, like anti-cancer, anti-microbial, anti-viral, anti-inflammatory, estrogenic, anti-oxidant, anti-neoplastic, anti-depressant, anti-Alzheimer, and anti-climacteric properties.
CONCLUSIONS: This article discusses the medicinal and traditional histories of various Cimicifuga species. Because quality control and safety assessments of Cimicifuga species are currently lacking, only a limited portion of the plant may be used as medication. The majority of current research focuses on triterpene glycosides. Although there are a variety of additional molecules that may have novel biological functions, systematic investigations of these compounds are lacking. The Cimicifuga plant has to go through a lot of studies before it can be completely used in clinics as a viable medicinal contender.
目的:本综合综述的目的是提供有关药理学的最新和详尽的知识,植物化学,和升麻的治疗特性。
方法:在这篇综述中,所有可用信息均收集于Cimicifugace.通过使用谷歌学者的计算机化搜索,PubMed,研究门,Sci-Hub,补充资源(书籍,政府报告,和博士学位论文)。
结果:对升麻属植物的植物化学研究。已经显示出植物成分,如三萜苷,类苯丙素,黄酮类化合物,皂苷,木脂素,含氮化合物,生物碱,4α-甲基类固醇和一些其他成分,如单萜内酯cimicfugolidesA-C等。Cimicifuga传达了广泛的体外和体内药理潜力研究,比如抗癌,抗微生物,抗病毒,抗炎,雌激素,抗氧化剂,抗肿瘤,抗抑郁药,抗阿尔茨海默氏症,和抗更年期特性。
结论:本文讨论了各种升麻物种的药用和传统历史。由于目前缺乏对Cimicifuga物种的质量控制和安全性评估,只有植物的有限部分可以用作药物。目前大多数研究集中在三萜苷上。虽然有多种额外的分子可能具有新的生物学功能,缺乏对这些化合物的系统研究。Cimicifuga植物必须经过大量研究才能完全用于临床作为可行的药用竞争者。