Abstract：
UNASSIGNED: Black cohosh, also known as Cimicifuga sp., is one of the most widely used ethnomedicine for the treatment of major health issues in women. Some reports show that Cimicifuga sp. exhibit anti-cancer, anti-viral, anti-microbial, anti-pyretic, and anti-inflammatory properties.
OBJECTIVE: The objective of this comprehensive review is to furnish current and exhaustive knowledge pertaining to the pharmacological, phytochemical, and therapeutic properties of Cimicifuga sp.
METHODS: In this review, all the available information was collected on Cimicifugasp. via computerized search using Google Scholar, PubMed, Research Gate, Sci-Hub, supplementary resources (books, government reports, and Ph.D. theses).
RESULTS: The phytochemical investigation on Cimicifuga sp. has shown phytoconstituents such as triterpenoid glycosides, phenylpropanoid, flavonoids, saponin, lignan, nitrogenous compounds, alkaloids, 4α-Methyl steroids and some other component like monoterpene lactones cimicifugolides A-C etc. Cimicifuga conveys a wide scope of research on in-vitro and in-vivo pharmacological potential, like anti-cancer, anti-microbial, anti-viral, anti-inflammatory, estrogenic, anti-oxidant, anti-neoplastic, anti-depressant, anti-Alzheimer, and anti-climacteric properties.
CONCLUSIONS: This article discusses the medicinal and traditional histories of various Cimicifuga species. Because quality control and safety assessments of Cimicifuga species are currently lacking, only a limited portion of the plant may be used as medication. The majority of current research focuses on triterpene glycosides. Although there are a variety of additional molecules that may have novel biological functions, systematic investigations of these compounds are lacking. The Cimicifuga plant has to go through a lot of studies before it can be completely used in clinics as a viable medicinal contender.
OBJECTIVE: The objective of this comprehensive review is to furnish current and exhaustive knowledge pertaining to the pharmacological, phytochemical, and therapeutic properties of Cimicifuga sp.
METHODS: In this review, all the available information was collected on Cimicifugasp. via computerized search using Google Scholar, PubMed, Research Gate, Sci-Hub, supplementary resources (books, government reports, and Ph.D. theses).
RESULTS: The phytochemical investigation on Cimicifuga sp. has shown phytoconstituents such as triterpenoid glycosides, phenylpropanoid, flavonoids, saponin, lignan, nitrogenous compounds, alkaloids, 4α-Methyl steroids and some other component like monoterpene lactones cimicifugolides A-C etc. Cimicifuga conveys a wide scope of research on in-vitro and in-vivo pharmacological potential, like anti-cancer, anti-microbial, anti-viral, anti-inflammatory, estrogenic, anti-oxidant, anti-neoplastic, anti-depressant, anti-Alzheimer, and anti-climacteric properties.
CONCLUSIONS: This article discusses the medicinal and traditional histories of various Cimicifuga species. Because quality control and safety assessments of Cimicifuga species are currently lacking, only a limited portion of the plant may be used as medication. The majority of current research focuses on triterpene glycosides. Although there are a variety of additional molecules that may have novel biological functions, systematic investigations of these compounds are lacking. The Cimicifuga plant has to go through a lot of studies before it can be completely used in clinics as a viable medicinal contender.
摘要：
■黑升麻,也称为Cimicifugasp.,是治疗妇女重大健康问题的最广泛使用的民族医学之一。一些报告显示Cimicifugasp.展示抗癌，抗病毒，抗微生物,解热,和抗炎特性。
目的：本综合综述的目的是提供有关药理学的最新和详尽的知识，植物化学，和升麻的治疗特性。
方法：在这篇综述中，所有可用信息均收集于Cimicifugace.通过使用谷歌学者的计算机化搜索，PubMed,研究门,Sci-Hub,补充资源(书籍，政府报告,和博士学位论文）。
结果：对升麻属植物的植物化学研究。已经显示出植物成分，如三萜苷，类苯丙素，黄酮类化合物，皂苷,木脂素,含氮化合物,生物碱，4α-甲基类固醇和一些其他成分，如单萜内酯cimicfugolidesA-C等。Cimicifuga传达了广泛的体外和体内药理潜力研究，比如抗癌，抗微生物,抗病毒，抗炎,雌激素,抗氧化剂，抗肿瘤,抗抑郁药,抗阿尔茨海默氏症，和抗更年期特性。
结论：本文讨论了各种升麻物种的药用和传统历史。由于目前缺乏对Cimicifuga物种的质量控制和安全性评估，只有植物的有限部分可以用作药物。目前大多数研究集中在三萜苷上。虽然有多种额外的分子可能具有新的生物学功能，缺乏对这些化合物的系统研究。Cimicifuga植物必须经过大量研究才能完全用于临床作为可行的药用竞争者。
目的：本综合综述的目的是提供有关药理学的最新和详尽的知识，植物化学，和升麻的治疗特性。
方法：在这篇综述中，所有可用信息均收集于Cimicifugace.通过使用谷歌学者的计算机化搜索，PubMed,研究门,Sci-Hub,补充资源(书籍，政府报告,和博士学位论文）。
结果：对升麻属植物的植物化学研究。已经显示出植物成分，如三萜苷，类苯丙素，黄酮类化合物，皂苷,木脂素,含氮化合物,生物碱，4α-甲基类固醇和一些其他成分，如单萜内酯cimicfugolidesA-C等。Cimicifuga传达了广泛的体外和体内药理潜力研究，比如抗癌，抗微生物,抗病毒，抗炎,雌激素,抗氧化剂，抗肿瘤,抗抑郁药,抗阿尔茨海默氏症，和抗更年期特性。
结论：本文讨论了各种升麻物种的药用和传统历史。由于目前缺乏对Cimicifuga物种的质量控制和安全性评估，只有植物的有限部分可以用作药物。目前大多数研究集中在三萜苷上。虽然有多种额外的分子可能具有新的生物学功能，缺乏对这些化合物的系统研究。Cimicifuga植物必须经过大量研究才能完全用于临床作为可行的药用竞争者。
