Abstract：
Due to its high information density, DNA is very attractive as a data storage system. However, a major obstacle is the high cost and long turnaround time for retrieving DNA data with next-generation sequencing. Herein, the use of a microfluidic very large-scale integration (mVLSI) platform is described to perform highly parallel and rapid readout of data stored in DNA. Additionally, it is demonstrated that multi-state data encoded in DNA can be deciphered with on-chip melt-curve analysis, thereby further increasing the data content that can be analyzed. The pairing of mVLSI network architecture with exquisitely specific DNA recognition gives rise to a scalable platform for rapid DNA data reading.
摘要：
由于其高信息密度，DNA作为数据存储系统非常有吸引力。然而,一个主要障碍是使用下一代测序检索DNA数据的高成本和长周转时间.在这里，描述了使用微流体超大规模集成（mVLSI）平台来执行存储在DNA中的数据的高度并行和快速读出。此外,证明了编码在DNA中的多态数据可以通过片上熔解曲线分析来解密，从而进一步增加可以分析的数据内容。mVLSI网络体系结构与精细特异性DNA识别的配对产生了用于快速DNA数据读取的可扩展平台。
