%0 Journal Article
%T Rapid Information Retrieval from DNA Storage with Microfluidic Very Large-Scale Integration Platform.
%A Liu DD
%A Cheow LF
%J Small
%V 20
%N 17
%D 2024 Apr 4
%M 38048539
%F 15.153
%R 10.1002/smll.202309867
%X Due to its high information density, DNA is very attractive as a data storage system. However, a major obstacle is the high cost and long turnaround time for retrieving DNA data with next-generation sequencing. Herein, the use of a microfluidic very large-scale integration (mVLSI) platform is described to perform highly parallel and rapid readout of data stored in DNA. Additionally, it is demonstrated that multi-state data encoded in DNA can be deciphered with on-chip melt-curve analysis, thereby further increasing the data content that can be analyzed. The pairing of mVLSI network architecture with exquisitely specific DNA recognition gives rise to a scalable platform for rapid DNA data reading.