PDF(Pubmed)
Abstract：
An 80-year-old man presented with electrolyte abnormalities, particularly hypocalcemia (3.6 mg/dL). He was diagnosed with bone and lymph node metastases from prostate cancer seven years earlier and continuously received goserelin, bicalutamide, and zoledronate. He later developed gradually worsening hypocalcemia, hypokalemia, hypophosphatemia, hypouricemia, renal dysfunction, and weight loss. Urinary potassium and phosphate loss, renal glucosuria, metabolic acidosis, and a low urine pH (5.0) were observed. Given the acquired onset and clinical course, we diagnosed the patient with zoledronate-induced proximal renal tubular acidosis. In the present case, severe hypocalcemia may have been caused by malnutrition and inappropriate long-term use of zoledronate.
摘要：
一名80岁的男子出现电解质异常，特别是低钙血症（3.6mg/dL）。七年前他被诊断出前列腺癌骨及淋巴结转移,并连续接受戈舍瑞林治疗,比卡鲁胺,和唑来膦酸盐.他后来出现了逐渐恶化的低钙血症,低钾血症,低磷酸盐血症,低尿酸血症,肾功能不全,和减肥。尿钾和磷酸盐丢失，肾性糖尿,代谢性酸中毒,观察到低尿液pH（5.0）。鉴于后天的发病和临床过程，我们诊断患者患有唑来膦酸诱导的近端肾小管酸中毒。在目前的情况下,严重的低钙血症可能是由营养不良和长期使用唑来膦酸不当引起的.
