Abstract：
The spread of antibiotic-resistant bacteria is a global problem that should be addressed through the perspective of the \"one health\" concept. The purpose of this study was to determine the contamination rate of antibiotic-resistant Aeromonas spp. in fresh water river fish purchased from a fish market in Vietnam. We then defined the pattern of antibiotic resistance to assess antibiotic-resistant contamination. Antibiotic-resistant Aeromonas spp. were detected in the intestinal contents of 32 of 80 fish. blaNDM-1 was detected in seven strains. Extended-spectrum β-lactamase and AmpC β-lactamase-related genes were detected in 28 strains, including blaCTX-M-55, blaCTX-M-15, blaCTX-M-1, and blaDHA,blaFOX, and blaMOX. The blaNDM-1 detected in the seven Aeromonas spp. strains were found chromosomally. This finding suggests that the blaNDM gene is stable in the natural environment and may spread widely into animals and humans via Aeromonas spp. with a transposon. Our results suggest the importance of continuing to monitor carbapenemase genes in Aeromonas spp. to evaluate the possibility that they may spread in other Enterobacterales, and to elucidate the mechanism of spread.
摘要：
抗生素抗性细菌的传播是一个全球性问题，应该从“一个健康”的角度来解决。本研究的目的是确定抗生素抗性气单胞菌属的污染率。在淡水河鱼从越南的一个鱼市场购买。然后，我们定义了抗生素耐药性的模式，以评估抗生素耐药性污染。耐抗生素气单胞菌属。在80条鱼的肠道内容物中检测到32。在7个菌株中检测到blaNDM-1。在28株菌株中检测到超广谱β-内酰胺酶和AmpCβ-内酰胺酶相关基因,包括blaCTX-M-55、blaCTX-M-15、blaCTX-M-1和blaDHA，BlaFOX,还有BlaMOX.在七个气单胞菌属中检测到blaNDM-1。菌株是在染色体上发现的。这一发现表明blaNDM基因在自然环境中稳定，并可能通过气单胞菌属广泛传播到动物和人类中。带有转座子。我们的结果表明，继续监测气单胞菌属碳青霉烯酶基因的重要性。为了评估它们在其他肠杆菌中传播的可能性，并阐明传播的机制。
