Abstract：
Pterocaulon genus comprises 26 species, half of them have been phytochemical investigations regarding the chemical composition, and coumarins have been considered the chemotaxonomic markers in the genus. Herein Pterocaulon angustifolium DC (Asteraceae), a native plant from Brazil, is investigated for the first time. Twenty-six compounds were isolated from aerial parts of P. angustifolium DC., being 5 triterpenes, 4 phytosterols, 9 flavonoids, 3 phenolic acids, and 5 coumarins. Moreover, a total of 177 compounds were putatively identified using the dereplication technique by UHPLC-HRMS/MS, more than 50% correspond to flavonoids and coumarins. Although 41 different coumarins have already been reported in Pterocaulon genus, 16 were identified for the first time in this study. Crude ethanolic extract and fractions of P. angustifolium were also biologically investigates, and dichloromethane fraction was the most active fraction in the evaluation of antiproliferative, antioxidant, antimicrobial and cholinesterase inhibitory activities.
摘要：
翼龙属包括26种，其中一半是关于化学成分的植物化学研究，香豆素被认为是该属中的化学分类学标记。这里是紫茎叶翅目DC(菊科)，一种来自巴西的本地植物，这是第一次被调查。26个化合物从沙棘DC的地上部分分离。,是5种三萜，4种植物甾醇，9类黄酮，3酚酸，5香豆素此外，通过UHPLC-HRMS/MS使用去复制技术推定鉴定了总共177个化合物，超过50%对应于类黄酮和香豆素。尽管已经在Pterocaulon属中报道了41种不同的香豆素，在这项研究中首次发现了16个。还进行了生物学研究，二氯甲烷部分是抗增殖评价中最活跃的部分，抗氧化剂，抗菌和胆碱酯酶抑制活性。
