Abstract：
Raised blood pressure is the most common complication worldwide that may lead to atherosclerosis and ischemic heart disease. Unhealthy lifestyles, smoking, alcohol consumption, junk food, and genetic disorders are some of the causes of hypertension. To treat this condition, numerous antihypertensive medications are available, either alone or in combination, that work via various mechanisms of action. Combinational therapy provides a certain advantage over monotherapy in the sense that it acts in multi mechanism mode and minimal drug amount is required to elicit the desired therapeutic effect. Such therapy is given to patients with systolic blood pressure greater than 20 mmHg and/or diastolic blood pressure exceeding 10 mmHg beyond the normal range, as well as those suffering from severe cardiovascular disease. The selection of antihypertensive medications, such as calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and low-dose diuretics, hinges on their ability to manage blood pressure effectively and reduce cardiovascular disease risks. This review provides insights into the diverse monotherapy and combination therapy approaches used for elevated blood pressure management. In addition, it offers an analysis of combination therapy versus monotherapy and discusses the current status of these therapies, from researchbased findings to clinical trials.
摘要：
血压升高是世界范围内最常见的并发症，可能导致动脉粥样硬化和缺血性心脏病。不健康的生活方式,吸烟,酒精消费,垃圾食品,遗传疾病是高血压的一些原因。为了治疗这种情况，有许多抗高血压药物，无论是单独还是组合，通过各种行动机制发挥作用。组合疗法提供了优于单一疗法的某些优点,即它以多机制模式起作用,并且需要最小的药物量来引起期望的治疗效果。此类治疗适用于收缩压大于20mmHg和/或舒张压超过10mmHg超出正常范围的患者，以及那些患有严重心血管疾病的人。抗高血压药物的选择，如钙通道阻滞剂，血管紧张素转换酶（ACE）抑制剂，血管紧张素受体阻滞剂（ARB），和低剂量利尿剂,取决于他们有效控制血压和降低心血管疾病风险的能力。这篇综述提供了对用于高血压管理的各种单一疗法和联合疗法方法的见解。此外,它提供了联合疗法与单一疗法的分析，并讨论了这些疗法的现状，从基于研究的发现到临床试验。
