METHODS: Relevant studies were sourced from MEDLINE and EMBASE databases. Relative risk (RR) or weighted mean difference (WMD) was analyzed as outcomes. A two-sided P value of less than 0.05 was regarded as statistical significance.
RESULTS: Forty-three studies comprising 11 601 patients with AP were included. The mortality was 28% for OF patients and 24% for those with IPN. Patients with OF without IPN had a significantly higher risk of mortality compared to those with IPN but without OF (RR 3.72, P < 0.0001). However, patients with both OF and IPN faced the highest risk of mortality. Additionally, IPN increased length of stay in hospital for OF patients (WMD 28.75, P = 0.032).
CONCLUSIONS: Though IPN remains a significant concern, which leads to increased morbidity and longer hospital stay, it is a less critical mortality determinant compared to OF in AP.
方法:相关研究来源于MEDLINE和EMBASE数据库。分析相对风险(RR)或加权平均差(WMD)作为结果。小于0.05的双侧P值被视为有统计学意义。
结果:纳入43项研究,包括11601例AP患者。OF患者的死亡率为28%,IPN患者的死亡率为24%。与没有IPN的患者相比,没有IPN的OF患者的死亡风险明显更高(RR3.72,P<0.0001)。然而,OF和IPN患者面临的死亡风险最高.此外,IPN增加了OF患者的住院时间(WMD28.75,P=0.032)。
结论:尽管IPN仍然是一个重要的问题,导致发病率增加和住院时间延长,与AP中的OF相比,它是一个不太关键的死亡率决定因素。