PDF(Pubmed)
Abstract：
Posterior reversible encephalopathy syndrome (PRES) is characterised by encephalopathy, visual disturbances and seizures, accompanied by radiological parieto-occipital oedema. Immunosuppressive and immunomodulatory drugs are risk factors. While capecitabine-induced PRES cases are rare, this report details a young woman with advanced gastric adenocarcinoma on capecitabine. She exhibited symptoms of nausea, vomiting and abdominal pain before developing hypertension, drowsiness and a seizure. Brain MRI revealed parieto-occipital hyperintense areas indicative of PRES. Suspending capecitabine led to a gradually improved mental state. Prompt recognition and treatment of PRES offer reversibility, often achievable through dose reduction or discontinuation of the causative drug.
摘要：
后部可逆性脑病综合征（PRES）的特征是脑病，视觉障碍和癫痫发作，伴有放射学上的枕骨水肿。免疫抑制和免疫调节药物是危险因素。虽然卡培他滨诱导的PRES病例很少见，本报告详细介绍了一名接受卡培他滨治疗的晚期胃腺癌的年轻女性。她表现出恶心的症状,在发展为高血压之前呕吐和腹痛，困倦和癫痫发作。脑部MRI显示顶枕骨高信号区，表明PRES。暂停卡培他滨导致精神状态逐渐改善。快速识别和处理PRES提供可逆性，通常可以通过减少剂量或停用致病药物来实现。
